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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,462 - 1,466 (5page)
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초록· 키워드
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Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Kochenderfer JN / 2017 / Lymphoma remissions caused by anti-CD19 chimeric antigen receptor T cells are associated with high serum interleukin-15 levels / J Clin Oncol 35:1803~1813
Turtle CJ / 2016 / CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients / J Clin Invest 126:2123~2138
Locke FL / 2017 / Phase 1 results of ZUMA-1: a multicenter study of KTE-C19 anti-CD19 CAR T cell therapy in refractory aggressive lymphoma / Mol Ther 25:285~295
Brudno JN / 2016 / Toxicities of chimeric antigen receptor T cells: recognition and management / Blood 127:3321~3330
Hu Y / 2016 / Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy / J Hematol Oncol 9:70
Turtle CJ / 2016 / CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients / J Clin Invest 126:2123~2138
Locke FL / 2017 / Phase 1 results of ZUMA-1: a multicenter study of KTE-C19 anti-CD19 CAR T cell therapy in refractory aggressive lymphoma / Mol Ther 25:285~295
Brudno JN / 2016 / Toxicities of chimeric antigen receptor T cells: recognition and management / Blood 127:3321~3330
Hu Y / 2016 / Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy / J Hematol Oncol 9:70
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