지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 261 - 269 (9page)
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초록· 키워드
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PurposeThe purpose of this study is to evaluate the outcome of low-dose whole brain radiotherapy(WBRT) with tumor bed boost after methotrexate-based chemotherapy in themanagement of primary central nervous system lymphoma (PCNSL).
Materials and MethodsWe retrospectively analyzed 64 patients with pathologically proven PCNSL between2000 and 2011. Methotrexate-based chemotherapy with a median of five cycles wasfollowed by radiotherapy to the whole brain and to the initial tumor bed. The mediandose to the whole brain and to the tumor bed was 27 Gy (range, 18 to 36 Gy) and 50.4Gy (range, 45 to 54 Gy), respectively.
ResultsWith a median follow-up period of 27 months, 55 patients (85.9%) achieved completeresponse (CR). The 5-year overall survival (OS) and progression-free survival (PFS)rates were 52.6% and 39.3%, respectively. In univariate analysis, factors associatedwith OS were age, performance status, involvement of deep structure, and CR tosequential chemoradiotherapy (CRT). These variables remained as significant factorsfor OS in multivariate analysis. CR to sequential CRT was the only positive factor associatedwith PFS (p=0.009). Neurologic toxicity was more common in elderly patientsolder than 60 years (p=0.025).
ConclusionLow-dose WBRT with tumor bed boost after methotrexate-based chemotherapy mightbe an effective method for management of PCNSL.
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참고문헌 (19)
참고문헌 신청
Bessell EM / 2002 / Importance of radiotherapy in the outcome of patients with primary CNS lymphoma : an analysis of the CHOD/BVAM regimen followed by two different radiothe
Brada M / 1998 / Short intensive primary chemotherapy and radiotherapy in sporadic primary CNS lymphoma(PCL) / Int J Radiat Oncol Biol Phys 40 : 1157 ~ 1162
Correa DD / 2012 / Cognitive functions in primary CNS lymphoma after single or combined modality regimens / Neuro Oncol 14 : 101 ~ 108
DeAngelis LM / 2002 / Radiation Therapy Oncology Group Study 93-10. Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy O
Ferreri AJ / 2011 / Consolidation radiotherapy in primary central nervous system lymphomas : impact on outcome of different fields and doses in patients in complete remissio
Brada M / 1998 / Short intensive primary chemotherapy and radiotherapy in sporadic primary CNS lymphoma(PCL) / Int J Radiat Oncol Biol Phys 40 : 1157 ~ 1162
Correa DD / 2012 / Cognitive functions in primary CNS lymphoma after single or combined modality regimens / Neuro Oncol 14 : 101 ~ 108
DeAngelis LM / 2002 / Radiation Therapy Oncology Group Study 93-10. Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy O
Ferreri AJ / 2011 / Consolidation radiotherapy in primary central nervous system lymphomas : impact on outcome of different fields and doses in patients in complete remissio
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