지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 243 - 249 (7page)
이용수
초록· 키워드
오류제보하기
PurposeThe aim of this study was to examine the clinical implications of a pathologically completeresponse after neoadjuvant chemoradiotherapy (CRT) followed by local excisionfor patients with cT2 rectal cancer who refused radical surgery.
Materials and MethodsSeventeen patients with cT2 primary rectal cancer within 6 cm from the anal vergewho received neoadjuvant CRT and local excision because of patient refusal of radicalsurgery or poor performance status were included. Two patients had clinical involvementof a regional lymph node. Preoperative radiotherapy was delivered to the wholepelvis at a dose of 44 to 50.4 Gy in 22 to 28 fractions. All patients underwent transanalexcision and eight patients (47%) received postoperative chemotherapy.
ResultsTen patients (59%) achieved ypT0. At a median follow-up period of 75 months (range,22 to 126 months), four (24%) patients developed recurrence (two locoregional andtwo distant). The 5-year disease-free survival of all patients was 82%, and was higherin patients with ypT0 (90%) than in patients with ypT1-2 (69%, p=0.1643). Decreaseddisease-free survival was also observed in patients receiving capecitabine comparedwith 5-fluorouracil (54% vs. 100%, p=0.0298).
ConclusionLocal excision could be a feasible alternative to radical surgery in patients with ypT0after neoadjuvant CRT for cT2 distal rectal cancer without further radical surgery.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Belluco C / 2011 / Long-term outcome of patients with complete pathologic response after neoadjuvant chemoradiation for cT3 rectal cancer : implications for local excision su
Bonnen M / 2004 / Long-term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients / Int J Radiat Oncol Biol Phys 60 : 1098
Borschitz T / 2008 / Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer / Ann Surg Oncol 15 : 712 ~ 720
Chan AK / 2010 / Preoperative capecitabine and pelvic radiation in locally advanced rectal cancer--is it equivalent to 5-FU infusion plus leucovorin and radiotherapy? / Int
Chessin DB / 2005 / Complications after preoperative combined modality therapy and radical resection of locally advanced rectal cancer : a 14-year experience from a specialty
Bonnen M / 2004 / Long-term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients / Int J Radiat Oncol Biol Phys 60 : 1098
Borschitz T / 2008 / Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer / Ann Surg Oncol 15 : 712 ~ 720
Chan AK / 2010 / Preoperative capecitabine and pelvic radiation in locally advanced rectal cancer--is it equivalent to 5-FU infusion plus leucovorin and radiotherapy? / Int
Chessin DB / 2005 / Complications after preoperative combined modality therapy and radical resection of locally advanced rectal cancer : a 14-year experience from a specialty
이 논문의 저자 정보
최근 본 자료
댓글(0)
0