지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 148 - 157 (10page)
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초록· 키워드
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PurposeThis study was designed to evaluate the impact of radiochemotherapeutic sequenceand time to initiation of adjuvant treatment on loco-regional control for resected stageII and III rectal cancer.
Materials and MethodsTreatment outcomes for rectal cancer patients from two hospitals with differentsequencing strategies regarding adjuvant concurrent radiochemotherapy (CRCT) werecompared retrospectively. Pelvic radiotherapy was administered concurrently on thefirst (early CRCT, n=180) or the third cycle of chemotherapy (late CRCT, n=180). Duringradiotherapy, two cycles of fluorouracil were provided to patients in both groups. Inthe early CRCT group, median six cycles of fluorouracil and leucovorin were prescribedduring the post-CRCT period. In the late CRCT group, two cycles of fluorouracil wereadministered in the pre- and post-CRCT periods.
ResultsNo significant differences in the 5-year loco-regional recurrence-free survival (LRRFS)(92.5% vs. 95.6%, p=0.43) or overall survival and disease-free survival were observedbetween groups. Patients who began receiving adjuvant treatment later than fiveweeks after surgery had lower LRRFS than patients who received adjuvant treatmentwithin five weeks following surgery (79% vs. 91%, p<0.01). The risk of loco-regionalrecurrence increased as the time to initiation of adjuvant treatment was delayed.
ConclusionIn the current study, treatment outcomes were not significantly influenced by thesequence of adjuvant treatment but by the delay of adjuvant treatment for more thanfive weeks. Timely administration of adjuvant treatment is deemed important inachieving loco-regional tumor control for stage II/III rectal cancer patients.
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참고문헌 (19)
참고문헌 신청
/ 1985 / Prolongation of the disease-free interval in surgically treated rectal carcinoma. Gastrointestinal Tumor Study Group / N Engl J Med 312 : 1465 ~ 1472
Adam IJ / 1994 / Role of circumferential margin involvement in the local recurrence of rectal cancer / Lancet 344 : 707 ~ 711
Ahmed S / 2010 / Early discontinuation but not the timing of adjuvant therapy affects survival of patients with high-risk colorectal cancer : a population-based study / Dis
Biagi JJ / 2011 / Association between time to initiation of adjuvant chemotherapy and survival in colorectal cancer : a systematic review and meta-analysis / JAMA 305 : 2335
Chau I / 2005 / A randomised comparison between 6 months of bolus fluorouracil/leucovorin and 12 weeks of protracted venous infusion fluorouracil as adjuvant treatment in co
Adam IJ / 1994 / Role of circumferential margin involvement in the local recurrence of rectal cancer / Lancet 344 : 707 ~ 711
Ahmed S / 2010 / Early discontinuation but not the timing of adjuvant therapy affects survival of patients with high-risk colorectal cancer : a population-based study / Dis
Biagi JJ / 2011 / Association between time to initiation of adjuvant chemotherapy and survival in colorectal cancer : a systematic review and meta-analysis / JAMA 305 : 2335
Chau I / 2005 / A randomised comparison between 6 months of bolus fluorouracil/leucovorin and 12 weeks of protracted venous infusion fluorouracil as adjuvant treatment in co
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