지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 158 - 168 (11page)
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PurposeTo evaluate the treatment outcomes of local excision following preoperative chemoradiotherapyin patients with locally advanced rectal cancer who have not undergoneradical surgery for any reason.
Materials and MethodsThe data of 27 patients with locally advanced rectal cancer who underwent preoperativechemoradiotherapy followed by local excision were analyzed retrospectively.
The primary endpoint was the 5-year relapse-free survival rate, and the secondaryendpoint was the pattern of recurrence.
ResultsThe median follow-up time was 81.8 months (range, 28.6 to 138.5 months).
The 5-year local relapse-free survival (LRFS), distant metastasis-free survival (DMFS),relapse-free survival (RFS), and overall survival (OS) were 88.9%, 81.1%, 77.8%, and85.0%, respectively. Six (22%) patients developed treatment failure; one (4%) patienthad local recurrence only, three (11%) patients had distant recurrence only, and two(7%) patients had both. The 5-year LRFS, DMFS, RFS, and OS for patients withypT0-1 compared with ypT2-3 were 94.1% vs. 77.8% (p=0.244), 94.1% vs. 55.6%(p=0.016), 88.2% vs. 55.6% (p=0.051), and 94.1% vs. 66.7% (p=0.073), respectively.
ConclusionLocal excision following preoperative chemoradiotherapy may be an alternative treatmentfor highly selected patients with locally advanced rectal cancer who haveachieved ypT0-1 after preoperative chemoradiotherapy.
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참고문헌 (22)
참고문헌 신청
/ / NCCN Clinical practice guidelines in oncology: rectal cancer
Bokkerink GM / 2011 / The CARTS study : chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery / BMC Surg 1
Bonnen M / 2004 / Long-term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients / Int J Radiat Oncol Biol Phys 60 : 1098
Borschitz T / 2008 / Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer / Ann Surg Oncol 15 : 712 ~ 720
Bujko K / 2007 / Local excision after radio (chemo) therapy for rectal cancer: is it safe? / Clin Oncol (R Coll Radiol) 19 : 693 ~ 700
Bokkerink GM / 2011 / The CARTS study : chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery / BMC Surg 1
Bonnen M / 2004 / Long-term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients / Int J Radiat Oncol Biol Phys 60 : 1098
Borschitz T / 2008 / Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer / Ann Surg Oncol 15 : 712 ~ 720
Bujko K / 2007 / Local excision after radio (chemo) therapy for rectal cancer: is it safe? / Clin Oncol (R Coll Radiol) 19 : 693 ~ 700
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