지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: Even though experimental studies have suggested that iron can be involved in generating oxidative stress,epidemiologic studies on the association of markers of body iron stores with cardiovascular disease or cancer remain controversial. This study was performed to examine the association of serum ferritin and transferrin saturation (%TS) with all-cause, cancer, and cardiovascular mortality.
Methods: The study subjects were men aged 50 years or older and postmenopausal women of the Third National Health and Nutrition Examination Survey 1988-1994. Participants were followed-up for mortality through December 31, 2006.
Results: Serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality for either men or postmenopausal women. However, all-cause, cancer, and cardiovascular mortality were inversely associated with %TS in men. Compared with men in the lowest quintile, adjusted hazard ratios for all-cause, cancer, and cardiovascular mortality were 0.85, 0.86, 0.76, and 0.74 (p for trend < 0.01), 0.82, 0.73, 0.75, and 0.63 (p for trend < 0.01), and 0.86, 0.81, 0.72,and 0.76 (p for trend < 0.01), respectively. For postmenopausal women, inverse associations were also observed for allcause and cardiovascular mortality, but cancer mortality showed the significantly lower mortality only in the 2nd quintile of %TS compared with that of the 1st quintile.
Conclusions: Unlike speculation on the role of iron from experimental studies, %TS was inversely associated with allcause,cancer and cardiovascular mortality in men and postmenopausal women. On the other hand, serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality.
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참고문헌 (24)
참고문헌 신청
/ 1994 / Plan and operation of the Third National Health and Nutrition Examination Survey, 1988-94, in Series 1: programs and collection procedures / Vital Health Stat 1 (32
Anderson RN / 2001 / Comparability of cause of death between ICD-9 and ICD- 10: preliminary estimates / Natl Vital Stat Rep 49 (2) : 1 ~ 32
Beaton GH / 1989 / Conceptual and methodological issues regarding the epidemiology of iron deficiency and their implications for studies of the functional consequences of ir
Centers for Disease Control and Prevention / / National Health and Nutrition Examination Survey: NCHS research ethics review board (ERB) approval
Charlson M / 1994 / Validation of a combined comorbidity index / J Clin Epidemiol 47 (11) : 1245 ~ 1251
Anderson RN / 2001 / Comparability of cause of death between ICD-9 and ICD- 10: preliminary estimates / Natl Vital Stat Rep 49 (2) : 1 ~ 32
Beaton GH / 1989 / Conceptual and methodological issues regarding the epidemiology of iron deficiency and their implications for studies of the functional consequences of ir
Centers for Disease Control and Prevention / / National Health and Nutrition Examination Survey: NCHS research ethics review board (ERB) approval
Charlson M / 1994 / Validation of a combined comorbidity index / J Clin Epidemiol 47 (11) : 1245 ~ 1251
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