지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: Although increased reactive oxygen species (ROS) is caused by stress accelerates collagen degradation,there was no data on the relationship between stress and urinary hydroxyproline (Hyp) and proline (Pro), a good marker of collagen degradation. The purpose of this study was to evaluate the relationship between depression, anxiety, and stress (DAS) and concentrations of urinary Hyp and Pro.
Methods: 97 hospital employees aged 20 to 58 were asked to fill out comprehensive self-administrated questionnaires containing information about their medical history, lifestyle, length of the work year, shit-work and DAS. Depression Anxiety Stress Scale (DASS) was applied to evaluate chronic mental disorders. Urine samples were analyzed using High Performance Liquid Chromatography (HPLC) with double derivatization for the assay of hydroxyproline and proline.
Results: The mean value of Hyp and Pro concenturation in all subjects was 194.1±113.4 μmol/g and 568.2±310.7μmol/g. DASS values and urinary Pro concentrations were differentiated by sex (female > male, p < 0.05) and type of job (nurse > others, p < 0.05). In the stepwise multiple linear regressions, urinary Hyp and Pro concentrations were influenced by stress (Adjusted r2 = 0.051) and anxiety and job (Adjusted r2 = 0.199), respectively.
Conclusions: We found that stress and anxiety were correlated with urinary Hyp and Pro concentrations. To identifying a definite correlation, further study in large populations will be needed.
목차
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참고문헌 (21)
참고문헌 신청
Bay E / 2005 / Chronic stress, salivary cortisol response, interpersonal relatedness, and depression among community-dwelling survivors of traumatic brain injury / J Neurosci
Bay E / 2009 / Functional status, chronic stress, and cortisol response after mild-to-moderate traumatic brain injury / Biol Res Nurs 10 (3) : 213 ~ 225
Brown TA / 1997 / Psychometric properties of the Depression Anxiety Stress Scales (DASS) in clinical samples / Behav Res Ther 35 (1) : 79 ~ 89
Cleutjens JP / 1995 / Regulation of collagen degradation in the rat myocardium after infarction / J Mol Cell Cardiol 27 (6) : 1281 ~ 1292
Crawford JR / 2003 / The Depression Anxiety Stress Scales (DASS): normative data and latent structure in a large non-clinical sample / Br J Clin Psychol 42 (2) : 111 ~ 131
Bay E / 2009 / Functional status, chronic stress, and cortisol response after mild-to-moderate traumatic brain injury / Biol Res Nurs 10 (3) : 213 ~ 225
Brown TA / 1997 / Psychometric properties of the Depression Anxiety Stress Scales (DASS) in clinical samples / Behav Res Ther 35 (1) : 79 ~ 89
Cleutjens JP / 1995 / Regulation of collagen degradation in the rat myocardium after infarction / J Mol Cell Cardiol 27 (6) : 1281 ~ 1292
Crawford JR / 2003 / The Depression Anxiety Stress Scales (DASS): normative data and latent structure in a large non-clinical sample / Br J Clin Psychol 42 (2) : 111 ~ 131
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