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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 18 - 25 (8page)
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초록· 키워드
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Purpose This prospective study was designed to verify the technical feasibility of partial breastirradiation in breast cancer patients with small breasts, which are commonly encounteredin Korean women.
Materials and MethodsA total of 40 Gy, administered in 10 fractions on consecutive days (one fraction per day),was prescribed to the isocenters of the fields using three-dimensional conformal radiotherapy(3-DCRT). For all patients, treatment planning and dose parameters strictly adhered tothe constraints set forth in the Radiation Therapy Oncology Group (RTOG) 0319 protocol.
This study was designed such that if fewer than five of the first 42 evaluable patients receivedunacceptable scores, the treatment would be considered reproducible.
ResultsTen treatment plans (23.8%) were determined to have major variations. There was no majorvariation in planning target volume (PTV) coverage. The ipsilateral and contralateral breastdose limitations were not met in four (9.5%) and four cases (9.5%), respectively. Majorvariations in ipsilateral and contralateral lung dose limitations were observed in two cases(4.8%). Major variations in the heart and thyroid dose limitations were observed in one(2.4%) and one case (2.4%), respectively. In multivariate analysis, a ratio of PTV to ipsilateralbreast volume (PTV/IB) > 0.16 was the only significant factor that statistically affected majorvariations.
ConclusionWe concluded that partial breast irradiation using 3-DCRT could not be reproduced inKorean breast cancer patients, particularly small-volumed breast surrogated as PTV/IB> 0.16. The dominant cause was the major variation in surrounding normal breast tissues.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Bergom C / 2013 / A phase I/II study piloting accelerated partial bre
Chang JH / 2013 / Phase II trial of proton beam accelerated partial breast irradiation in breast cancer / Radiother Oncol 108 : 209 ~ 214
Dzhugashvili M / 2010 / Surgical clips assist in the visualization of the lumpectomy cavity in three-dimensional conformal accelerated partial-breast irradiation / Int J Rad
Fowble B / 1990 / Breast recurrence following conservative surgery and radiation : patterns of failure, prognosis, and pathologic findings from mastectomy specimens with impl
Harris JR / 1979 / Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast / Int J Radiat Oncol Biol Phys 5 : 257 ~ 261
Chang JH / 2013 / Phase II trial of proton beam accelerated partial breast irradiation in breast cancer / Radiother Oncol 108 : 209 ~ 214
Dzhugashvili M / 2010 / Surgical clips assist in the visualization of the lumpectomy cavity in three-dimensional conformal accelerated partial-breast irradiation / Int J Rad
Fowble B / 1990 / Breast recurrence following conservative surgery and radiation : patterns of failure, prognosis, and pathologic findings from mastectomy specimens with impl
Harris JR / 1979 / Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast / Int J Radiat Oncol Biol Phys 5 : 257 ~ 261
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