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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제45권 제4호
발행연도
2013.1
수록면
263 - 269 (7page)

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Purpose End-of-dose failure (EOD) is a clinically common observation and many cancer patients increase the frequency of opioid administration. Fentanyl matrix use is known to be effective in patients with chronic cancer pain. To measure the effectiveness of increase in a single dose of fentanyl matrix in patients whose pain was not controlled sufficiently, we perform this study. Materials and Methods A multi-center, open-label, prospective, observational study was conducted in 30hospitals in Korea, between August and December 2008. Results A total of 452 patients were enrolled; 404 patients completed the study. The mean pain intensity decreased from 5.27 at the first visit to 3.37 at the end of the trial. There was a significant difference in pain intensity (p < 0.001) between the first and last visits. The percentage of pain intensity difference was 30.1%. The prevalence of EOD at the first visit was 73% from the 452 enrolled patients. After the use of fentanyl patch, EOD decreased from 73% to 56%. Pain intensity of patients experiencing EOD was 5.64 at the baseline compared to 4.27 in patients without EOD. On final visit,pain intensity in patients with and without EOD was 4.02 and 2.54, respectively. The observed adverse events were mainly nausea, asthenia, constipation and diarrhea. Conclusion This study demonstrated that increasing dose of fentanyl patch decreased pain intensity and decreased the rate of patients experiencing EOD. Thus, fentanyl patch may be an effective modality in cancer patients whose pain was previously not controlled sufficiently; the side effects were as could be expected with an opioid.
#Fentanyl #Neoplasms #Pain

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참고문헌 (22)

참고문헌 신청
Adams D / 2002 / Retrospective assessment of frequency of dosing of sustained release opiate preparations in chronic pain patients / Pain Med 3 : 185 ~ google schola Bercovitch M / 2004 / Patterns of high-dose morphine use in a home-care hospice service: should we be afraid of it / Cancer 101 : 1473 ~ 1477 google schola Fishbain DA / 2008 / Pharmacotherapeutic management of breakthrough pain in patients with chronic persistent pain / Am J Manag Care 14 (5 Suppl 1) : S123 ~ S128 google schola Gallagher RM / 2007 / Assessment of dosing frequency of sustained-release opioid preparations in patients with chronic nonmalignant pain / Pain Med 8 : 71 ~ 74 google schola Jeal W / 1997 / Transdermal fentanyl : a review of its pharmacological properties and therapeutic efficacy in pain control / Drugs 53 : 109 ~ 138 google schola

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