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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 561 - 566 (6page)
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Purpose Restaging after neoadjuvant treatment is done for planning the surgical approach and, increasingly, to determine whether additional therapy or resection can be avoided for selected patients.
Materials and Methods Local restaging after neoadjuvant chemoradiation therapy (nCRT) was performed in 270 patients with locally advanced (cT3or4 or N+) rectal cancer. Abdomen and pelvic computed tomography (APCT) was used in all 270 patients, transrectal ultrasound (TRUS) in 121 patients, and rectal magnetic resonance imaging (MRI) in 65 patients. Findings according to imaging modalities were correlated with pathologic stage using Cohen’s kappa (!) to test agreement and intra-class correlation coefficient " to test reliability.
Results Accuracy for prediction of yp T stage according to three imaging modalities was 45.2% (!=0.136, "=0.380) in APCT, 49.2% (!=0.259, "=0.514) in rectal MRI, and 57.9% (!=0.266, "=0.520) in TRUS. Accuracy for prediction of yp N stage was 66.0% (!=0.274, "=0.441) in APCT, 71.8% (!=0.401, "=0.549) in rectal MRI, and 66.1% (!=0.147, "=0.272) in TRUS. Of 270 patients, 37 (13.7%) were diagnosed as pathologic complete responder after nCRT. Rectal MRI for restaging did not predict complete response. On the other hand, TRUS did predict three complete responders (!=0.238, "=0.401).
Conclusion APCT, rectal MRI, and TRUS are unreliable in restaging rectal cancer after nCRT. We think that multimodal assessment with rectal MRI and TRUS may be the best option for local restaging of locally advanced rectal cancer after nCRT.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Sauer R / 2004 / Preoperative versus postoperative chemoradiotherapy for rectal cancer / N Engl J Med 351:1731~1740
Kapiteijn E / 2001 / Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer / N Engl J Med 345:638~646
Theodoropoulos G / 2002 / T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival / Dis Colon Rectum 45:895~903
Van Cutsem E / 2008 / The diagnosis and management of rectal cancer : expert discussion and recommendations derived from the 9th World Congress on Gastrointestinal Cancer, Barcelona, 2007 / Ann Oncol 19(Suppl 6):1~8
Kim CJ / 2001 / Local excision of T2 and T3 rectal cancers after downstaging chemoradiation / Ann Surg 234:352~358
Kapiteijn E / 2001 / Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer / N Engl J Med 345:638~646
Theodoropoulos G / 2002 / T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival / Dis Colon Rectum 45:895~903
Van Cutsem E / 2008 / The diagnosis and management of rectal cancer : expert discussion and recommendations derived from the 9th World Congress on Gastrointestinal Cancer, Barcelona, 2007 / Ann Oncol 19(Suppl 6):1~8
Kim CJ / 2001 / Local excision of T2 and T3 rectal cancers after downstaging chemoradiation / Ann Surg 234:352~358
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