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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 843 - 847 (5page)
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초록· 키워드
오류제보하기
Leptomeningeal carcinomatosis is a fatal manifestation of metastatic breast cancer.
Investigation of intrathecal (IT) trastuzumab for leptomeningeal carcinomatosis is currently underway; however, there has been no consensus. We report on two cases of human epidermal growth factor receptor 2 positive (HER2+) breast cancer following IT trastuzumab for leptomeningeal carcinomatosis. The first patient was treated with weekly IT 15 mg methotrexate plus IT 50 mg trastuzumab for 7 months, followed by IT trastuzumab (50 mg > 25 mg) for 18 months. The other patient received IT trastuzumab with systemic chemotherapy (trastuzumab and/or paclitaxel) for 13 months.
Good control of leptomeningeal disease was achieved with IT trastuzumab in both patients, with survival durations of 20 and 29 months, respectively. We suggest that IT trastuzumab is a promising treatment for patients with HER2+ breast cancer and leptomeningeal carcinomatosis.
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등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Grossman SA / 1999 / Leptomeningeal carcinomatosis / Cancer Treat Rev 25:103~119
Jayson GC / 1996 / Carcinomatous meningitis in solid tumours / Ann Oncol 7:773~786
Pienkowski T / 2010 / Trastuzumab treatment in patients with breast cancer and metastatic CNS disease / Ann Oncol 21:917~924
Zagouri F / 2013 / Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer : a systematic review and pooled analysis / Breast Cancer Res Treat 139:13~22
Clarke JL / 2010 / Leptomeningeal metastases in the MRI era / Neurology 74:1449~1454
Jayson GC / 1996 / Carcinomatous meningitis in solid tumours / Ann Oncol 7:773~786
Pienkowski T / 2010 / Trastuzumab treatment in patients with breast cancer and metastatic CNS disease / Ann Oncol 21:917~924
Zagouri F / 2013 / Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer : a systematic review and pooled analysis / Breast Cancer Res Treat 139:13~22
Clarke JL / 2010 / Leptomeningeal metastases in the MRI era / Neurology 74:1449~1454
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