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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 240 - 249 (10page)
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Purpose Anorectal malignant melanomas (AMM) are rare and have poor survival. The study aims to evaluate the clinicopathologic characteristics and outcomes of patients with AMM, and to devise a staging system predictive of survival outcome.
Materials and Methods This was a retrospective study of 28 patients diagnosed with, and treated for AMM. Patients classified by clinical staging of mucosal melanoma (MM) were reclassified via rectal and anal TNM staging. Survival outcomes were compared among patients grouped by the three different staging systems.
Results The three staging systems were equated with similar figures for 5-year overall survival (OS) and 5-year disease-free survival (DFS) of patients diagnosed with stage I disease. Patients (n=19) diagnosed with MM stage II disease were reclassified by rectal TNM staging into three subgroups: IIIA, IIIB, and IIIC. For these patients, both 5-year OS and 5-year DFS differed significantly between the subgroups IIIA and IIIC (OS: IIIA vs. IIIC, 66.7% vs. 0%, p=0.002; DFS: IIIA vs. IIIC, 51.4% vs. 0%, p < 0.001).
Conclusion The accuracy of prognosis in patients diagnosed with AMM and lymph node metastasis has improved by using rectal TNM staging, which includes information regarding the number of lymph node metastases.
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참고문헌 (24)
참고문헌 신청
Belbaraka R / 2012 / Management of anorectal melanoma : report of 17 cases and literature review / J Gastrointest Cancer 43:31~35
Chang AE / 1998 / The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society / Cancer 83:1664~1678
Falch C / 2013 / Anorectal malignant melanoma : extensive 45-year review and proposal for a novel staging classification / J Am Coll Surg 217:324~335
Banerjee SS / 2000 / Morphological and immunophenotypic variations in malignant melanoma / Histopathology 36:387~402
Roumen RM / 1996 / Anorectal melanoma in The Netherlands : a report of 63 patients / Eur J Surg Oncol 22:598~601
Chang AE / 1998 / The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society / Cancer 83:1664~1678
Falch C / 2013 / Anorectal malignant melanoma : extensive 45-year review and proposal for a novel staging classification / J Am Coll Surg 217:324~335
Banerjee SS / 2000 / Morphological and immunophenotypic variations in malignant melanoma / Histopathology 36:387~402
Roumen RM / 1996 / Anorectal melanoma in The Netherlands : a report of 63 patients / Eur J Surg Oncol 22:598~601
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