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Can Anorectal Manometry Findings Predict Subsequent Late Gastrointestinal Radiation Toxicity in Prostate Cancer Patients?
Can Anorectal Manometry Findings Predict Subsequent Late Gastrointestinal Radiation Toxicity in Prostate Cancer Patients?
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제48권 제1호 KCI Accredited Journals
- 발행연도
- 2016.1
- 수록면
- 297 - 303 (7page)
이용수
Can Anorectal Manometry Findings Predict Subsequent Late Gastrointestinal Radiation Toxicity in Prostate Cancer Patients?
초록· 키워드
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Purpose The purpose of this study is to investigate the influence of radiotherapy (RT) on anorectal function and radiation-induced toxicity in patients with prostate cancer.
Materials and Methods Fifty-four patients who were treated with RT for prostate cancer (T1c-4N0-1M0) were eval- uated. To assess the changes in anorectal function, two consecutive anorectal manometry readings were performed in patients, before and after 4-6 months of RT. Late gastrointesti- nal (GI) toxicity was defined as symptoms occurring more than 6 months after RT. The median radiation dose was 70.0 Gy (range, 66.0 to 74.0 Gy). Whole pelvis field RT was per- formed in 16 patients (29.6%). Grade of late radiation toxicity was defined in accordance to the severity of symptoms (Gulliford’s scoring system).
Results The median follow-up period was 60 months. Resting anal pressure (p=0.001), squeeze pressure (p < 0.001), and urge to defecate volume (p=0.025) were significantly reduced after RT. Fourteen patients (25.9%) experienced late GI toxicities. Among them, nine (16.7%) showed severe (grade ! 2) late toxicities. Elevated resting and squeeze external anal sphinc- ter pressure prior to RT and large urge to defecate volumes after RT were associated with the occurrence of late GI toxicities.
Conclusion RT caused symptomatic anorectal dysfunction and resulted in a weakened anal sphincter. Increased urge to defecate volumes after RT were related to late GI toxicities. Elevated rest- ing and squeeze anal sphincter pressure prior to RT rodcan be used to identify patients with an increased risk of late GI toxicities.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Yeoh EK / 2009 / Anorectal function after three-versus twodimensional radiation therapy for carcinoma of the prostate / Int J Radiat Oncol Biol Phys 73:46~52
Smeenk RJ / 2012 / Differences in radiation dosimetry and anorectal function testing imply that anorectal symptoms may arise from different anatomic substrates / Int J Radiat Oncol Biol Phys 82:145~152
Mantini G / 2011 / Effect of whole pelvic radiotherapy for patients with locally advanced prostate cancer treated with radiotherapy and long-term androgen deprivation therapy / Int J Radiat Oncol Biol Phys 81:721~726
Yeoh EK / 2010 / Disturbed colonic motility contributes to anorectal symptoms and dysfunction after radiotherapy for carcinoma of the prostate / Int J Radiat Oncol Biol Phys 78:773~780
Yeoh EK / 2012 / Pathophysiology and natural history of anorectal sequelae following radiation therapy for carcinoma of the prostate / Int J Radiat Oncol Biol Phys 84:593~599
Smeenk RJ / 2012 / Differences in radiation dosimetry and anorectal function testing imply that anorectal symptoms may arise from different anatomic substrates / Int J Radiat Oncol Biol Phys 82:145~152
Mantini G / 2011 / Effect of whole pelvic radiotherapy for patients with locally advanced prostate cancer treated with radiotherapy and long-term androgen deprivation therapy / Int J Radiat Oncol Biol Phys 81:721~726
Yeoh EK / 2010 / Disturbed colonic motility contributes to anorectal symptoms and dysfunction after radiotherapy for carcinoma of the prostate / Int J Radiat Oncol Biol Phys 78:773~780
Yeoh EK / 2012 / Pathophysiology and natural history of anorectal sequelae following radiation therapy for carcinoma of the prostate / Int J Radiat Oncol Biol Phys 84:593~599
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