지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 215 - 220 (6page)
이용수
초록· 키워드
오류제보하기
Purpose We previously reported the prevalence of monoclonal gammopathy of undeterminedsignificance (MGUS) to be 3.3% among an elderly Korean urban cohort recruited during2005-2006. Here, we report a 5-year follow-up study of the previously identified MGUScohort.
Materials and MethodsThe 680 participants from the initial cohort were followed-up for a median of 5 years. Serawere collected between 2010 and 2011. Two-step screening was performed with standardserum electrophoresis followed by immunofixation and determination of the serumconcentration of monoclonal-protein (M-protein).
ResultsOf the 680 participants (21 with MGUS), 348 (51%) agreed to participate in the follow-upstudy and 10 were found to have MGUS. Among the 21 MGUS patients initially identified,nine were followed-up, six had persistent M-protein, and one patient had progressed tomultiple myeloma (progression rate, 1.0%/yr). The M-protein disappeared in the remainingtwo individuals. Among the 339 participants without MGUS who were followed-up, fourdeveloped an M-protein. There was no significant difference in survival with respect to thepresence of MGUS (p=0.66).
ConclusionThe 5-year follow-up data show that the natural clinical course of MGUS in Korea is similarto that in Western countries. MGUS was not associated with an increased risk of death overthe 5-year study period.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Blade J / 2008 / Pathogenesis and progression of monoclonal gammopathy of undetermined significance / Leukemia 22 : 1651 ~ 1657
Gregersen H / 2001 / Mortality and causes of death in patients with monoclonal gammopathy of undetermined significance / Br J Haematol 112 : 353 ~ 357
Iwanaga M / 2007 / Prevalence of monoclonal gammopathy of undetermined significance : study of 52, 802 persons in Nagasaki City, Japan / Mayo Clin Proc 82 : 1474 ~ 1479
Kyle RA / 2002 / A long-term study of prognosis in monoclonal gammopathy of undetermined significance / N Engl J Med 346 : 564 ~ 569
Kyle RA / 2003 / Long-term follow-up of IgM monoclonal gammopathy of undetermined significance / Blood 102 : 3759 ~ 3764
Gregersen H / 2001 / Mortality and causes of death in patients with monoclonal gammopathy of undetermined significance / Br J Haematol 112 : 353 ~ 357
Iwanaga M / 2007 / Prevalence of monoclonal gammopathy of undetermined significance : study of 52, 802 persons in Nagasaki City, Japan / Mayo Clin Proc 82 : 1474 ~ 1479
Kyle RA / 2002 / A long-term study of prognosis in monoclonal gammopathy of undetermined significance / N Engl J Med 346 : 564 ~ 569
Kyle RA / 2003 / Long-term follow-up of IgM monoclonal gammopathy of undetermined significance / Blood 102 : 3759 ~ 3764
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