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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제43권 제1호
발행연도
2011.1
수록면
32 - 41 (10page)

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Purpose To evaluate treatment outcomes and prognostic factors in non-small cell lung cancer (NSCLC)patients treated with concurrent chemoradiation. Materials and Methods From January 2005 to June 2009, 51 patients were treated with concurrent chemoradiation for 3 different aims: locally advanced stage III, locally recurrent disease, and postoperative gross residual NSCLC. Median age was 63 years. Distribution of stages by the 6th edition of American Joint Committee on Cancer (AJCC) was as follows: IIIA (37.3%), IIIB (56.9%). Chemotherapy was administered every week concurrently with radiation using one of the following regimens: paclitaxel (60 mg/m2), docetaxel+cisplatin (20 mg/m2+20 mg/m2), cisplatin (30 mg/m2). Total radiation dose was 16-66.4 Gy (median, 59.4 Gy). Results Median follow-up duration was 40.8 months. The overall response rate was 84.3% with 23complete responses. The median survival duration for the overall patient group was 17.6months. The 3-year survival rate was 17.8%. A total of 21 patients had recurrent disease at the following sites: loco-regional sites (23.6%), distant organs (27.5%). In the multivariate analysis of the overall patient group, a clinical tumor response (p=0.002) was the only significant prognostic factor for overall survival (OS). In the multivariate analysis of the definitive chemoradiation arm, the use of consolidation chemotherapy (p=0.022), biologically equivalent dose (BED)10 (p=0.007),and a clinical tumor response (p=0.030) were the significant prognostic factors for OS.The median survival duration of the locally recurrent group and the postoperative gross residual group were 26.4 and 23.9 months, respectively. Conclusion Our study demonstrated that clinical tumor response was significantly associated with OS in the overall patient group. Further investigations regarding the optimal radiation dose in the definitive chemoradiation and the optimal treatment scheme in locally recurrent NSCLC would be required.
#Non-small cell lung cancer #Concurrent chemoradiation #Prognostic factor #Recurrent non-small cell lung cancer

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참고문헌 신청
Firat S / 2002 / Comorbidity and Karnofksy performance score are independent prognostic factors in stage III non-small-cell lung cancer: an institutional analysis of patients treated on four RTOG studies. Radiation Therapy Oncology Group / Int J Radiat Oncol Biol Phys 54:357~364 google schola Ademuyiwa FO / 2007 / Prognostic factors in stage III non-small-cell lung cancer / Clin Lung Cancer 8:478~482 google schola Kelly K / 2008 / Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023 / J Clin Oncol 26:2450~2456 google schola Park K / 2009 / A multinational phase III randomized trial with or without consolidation chemotherapy using docetaxel and cisplatin after concurrent chemoradiation in inoperable stage III non-small cell lung cancer (CCheIN): interim analysis / J Clin Oncol 27(15s):7538 google schola Rengan R / 2004 / Improved local control with higher doses of radiation in large-volume stage III nonsmall-cell lung cancer / Int J Radiat Oncol Biol Phys 60:741~747 google schola

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