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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제44권 제1호
발행연도
2012.1
수록면
43 - 49 (7page)

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Purpose The combination of gemcitabine and docetaxel (GD) is used to effectively treat patients with soft tissue sarcoma (STS). It is widely considered that the conventional doses used are too high for long term use and many patients must discontinue GD treatment due to its toxicity. Therefore, to determine the appropriate dose meeting acceptable efficacy results, while minimizing toxic side effects, we treated patients with a weekly infusion of GD (weekly GD). Materials and Methods A total of 22 patients presenting a variety of STSs were treated at Yonsei Cancer Center. All patients had metastatic or recurrent cancer and had previously received doxorubicin and ifosfamide combination chemotherapy. In all cases, gemcitabine (1,000 mg/m2) and docetaxel (35 mg/m2) were administered intravenously on days 1 and 8 of a 21-day cycle. We retrospectively reviewed the medical records of these patients. Results The response rate was 4.5%, with one patient diagnosed with leiomyosarcoma having a partial response, and the disease control rate was 40.9%. The median progression-free survival (PFS)duration was 2.7 months and the PFS was correlated with the treatment response to a weekly GD. The median overall survival (OS) duration was 7.8 months and the OS was correlated with histology. There was no significant difference in OS between patients who received weekly GD as a 2nd line chemotherapy and those who received 3rd line or more. Treatment was generally well tolerated. Conclusion Weekly GD was well tolerated and showed moderate efficacy, indicating that this could be a reasonable option as a salvage treatment for metastatic STS.
#Refractory soft-tissue sarcoma #Docetaxel #Gemcitabine #Weekly

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참고문헌 (22)

참고문헌 신청
Aihara T / 2002 / Phase II study of weekly docetaxel in patients with metastatic breast cancer / Ann Oncol 13 : 286 ~ 292 google schola Bay JO / 2006 / Docetaxel and gemcitabine combination in 133 advanced soft-tissue sarcomas : a retrospective analysis / Int J Cancer 119 : 706 ~ 711 google schola Edmonson JH / 1996 / Phase II study of docetaxel in advanced soft tissue sarcomas / Am J Clin Oncol 19 : 574 ~ 576 google schola Georgoulias V / 1999 / Front-line treatment of advanced non-small-cell lung cancer with docetaxel and gemcitabine : a multicenter phase II trial / J Clin Oncol 17 : 914 ~ 92 google schola Hensley ML / 2002 / Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma : results of a phase II trial / J Clin Oncol 20 : 2824 ~ 2831 google schola

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