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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 804 - 812 (9page)
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Purpose We investigated the relationships between biomarkers related to endoplasmic reticulumstress proteins (glucose-regulated protein of molecular mass 78 [GRP78] and Cripto-1[teratocarcinoma-derived growth factor 1 protein]), pathologic response, and prognosis inlocally advanced rectal cancer.
Materials and MethodsAll clinical stage II and III rectal cancer patients received 50.4 Gy over 5.5 weeks, plus 5-fluorouracil (400 mg/m2/day) and leucovorin (20 mg/m2/day) bolus on days 1 to 5 and 29to 33, and surgery was performed at 7 to 10 weeks after completion of all therapies.
Expression of GRP78 and Cripto-1 proteins was determined by immunohistochemistry andwas assessed in 101 patients with rectal cancer treated with neoadjuvant chemoradiotherapy(CRT).
ResultsHigh expression of GRP78 and Cripto-1 proteins was observed in 86 patients (85.1%) and49 patients (48.5%), respectively. Low expression of GRP78 protein was associated with asignificantly high rate of down staging (80.0% vs. 52.3%, respectively; p=0.046) and asignificantly low rate of recurrence (0% vs. 33.7%, respectively; p=0.008) compared withhigh expression of GRP78 protein. Mean recurrence-free survival according to GRP78expression could not be estimated because the low expression group did not developrecurrence events but showed a significant correlation with time to recurrence, based onthe log rank method (p=0.007). GRP78 also showed correlation with overall survival, basedon the log rank method (p=0.045).
ConclusionGRP78 expression is a predictive and prognostic factor for down staging, recurrence, andsurvival in rectal cancer patients treated with 5-fluorouracil and leucovorin neoadjuvantCRT.
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참고문헌 (18)
참고문헌 신청
Ciardiello F / 1991 / Differential expression of epidermal growth factorrelated proteins in human colorectal tumors / Proc Natl Acad Sci U S A 88 : 7792 ~ 7796
De Caluwe L / 2013 / Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer / Cochrane Database Syst Rev 2 : CD006041 ~
Ertoy D / 2000 / Clinicopathological implication of cripto expression in early stage invasive cervical carcinomas / Eur J Cancer 36 : 1002 ~ 1007
Feng XP / 2010 / Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics / Cancer Res 70 : 3450 ~ 3462
Kelber JA / 2009 / Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways / Oncogene 28 : 2324 ~ 2336
De Caluwe L / 2013 / Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer / Cochrane Database Syst Rev 2 : CD006041 ~
Ertoy D / 2000 / Clinicopathological implication of cripto expression in early stage invasive cervical carcinomas / Eur J Cancer 36 : 1002 ~ 1007
Feng XP / 2010 / Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics / Cancer Res 70 : 3450 ~ 3462
Kelber JA / 2009 / Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways / Oncogene 28 : 2324 ~ 2336
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