지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 74 - 80 (7page)
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초록· 키워드
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PurposeVaginal intraepithelial neoplasia (VAIN), a rare premalignant condition, is difficult toeradicate. We assess the effectiveness of high-dose rate intracavitary brachytherapy(HDR-ICR) in patients with VAIN or carcinoma in situ (CIS) of the vagina after hysterectomy.
Materials and MethodsWe reviewed 34 patients treated for posthysterectomy VAIN or CIS of the vagina bybrachytherapy as the sole treatment. All patients underwent a coloposcopic-directedpunch biopsy or had abnormal cytology, at least 3 consecutive times. All patients weretreated with a vaginal cylinder applicator. The total radiation dose was mainly 40 Gyin 8 fractions during the periods of 4 weeks at a prescription point of the median 0.2 cm(range, 0 to 0.5 cm) depth from the surface of the vaginal mucosa.
ResultsAcute toxicity was minimal. Seven patients had grade 1/2 acute urinary and rectalcomplications. There were 15 cases of late toxicity, predominantly vaginal mucosalreaction in 12 patients. Of these patients, two patients suffered from grade 3 vaginalstricture and dyspareunia continuously. After a median follow-up time of 48 months(range, 4 to 122 months), there were 2 recurrences and 2 persistent diseases, inwhich a second-line therapy was needed. The success rate was 88.2%. The averageprescription point in failure patients was 1.1 mm from the surface of the vaginacompared to an average of 2.6 mm in non-recurrent patients (p=0.097).
ConclusionHDR-ICR is an effective treatment method in VAIN patients. In spite of high cure rates,we should consider issues regarding vaginal toxicity and radiation techniques toreduce the occurrence of failure and toxicity.
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참고문헌 (13)
참고문헌 신청
Aho M / 1991 / Natural history of vaginal intraepithelial neoplasia / Cancer 68 : 195 ~ 197
Audet-Lapointe P / 1990 / Vaginal intraepithelial neoplasia / Gynecol Oncol 36 : 232 ~ 239
Blanchard P / 2011 / Low-dose-rate definitive brachytherapy for high-grade vaginal intraepithelial neoplasia / Oncologist 16 : 182 ~ 188
Dodge JA / 2001 / Clinical features and risk of recurrence among patients with vaginal intraepithelial neoplasia / Gynecol Oncol 83 : 363 ~ 369
Gemmell J / 1990 / How frequently need vaginal smears be taken after hysterectomy for cervical intraepithelial neoplasia? / Br J Obstet Gynaecol 97 : 58 ~ 61
Audet-Lapointe P / 1990 / Vaginal intraepithelial neoplasia / Gynecol Oncol 36 : 232 ~ 239
Blanchard P / 2011 / Low-dose-rate definitive brachytherapy for high-grade vaginal intraepithelial neoplasia / Oncologist 16 : 182 ~ 188
Dodge JA / 2001 / Clinical features and risk of recurrence among patients with vaginal intraepithelial neoplasia / Gynecol Oncol 83 : 363 ~ 369
Gemmell J / 1990 / How frequently need vaginal smears be taken after hysterectomy for cervical intraepithelial neoplasia? / Br J Obstet Gynaecol 97 : 58 ~ 61
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