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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 55 - 64 (10page)
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PurposeThe novel heat shock protein tumor necrosis factor receptor-associated protein 1(TRAP1) is associated with multidrug resistance in colorectal cancer (CRC) cells invitro. Excision repair cross-complementation group 1 (ERCC1) expression levels intumor tissues also predict clinical outcomes in metastatic CRC patients receivingcombination oxaliplatin and 5-fluorouracil treatment. We investigated whether TRAP1and ERCC1 protein expression by immunohistochemistry predict clinical outcomes inCRC patients.
Materials and MethodsThe study population consisted of 56 patients with metastatic CRC who receivedfirst-line oxaliplatin/5-fluorouracil therapy. Clinical response and overall survival (OS)by levels of the markers TRAP1 and ERCC1 were evaluated.
ResultsThe rates of TRAP1 and ERCC1 expression were 21% and 52%, respectively. Patientsnegative for ERCC1 expression showed a tendency to respond to chemotherapy(p=0.066). Median OS was significantly longer in patients negative for TRAP1 thanthose positive for TRAP1 (p=0.023). Patients negative for ERCC1 expression also hada better OS than those positive for ERCC1 (p=0.021). The median OS was 30.9months for patients negative for TRAP1 and ERCC1 compared to 13.2 months forthose positive for TRAP1 and/or positive for ERCC1 expression (p=0.006). Thecombination of TRAP1 and ERCC1 expression was significantly associated with theresponse to chemotherapy (p=0.046) and independently predicted median OS inmultivariate analysis (hazard ratio, 2.98; 95% confidence interval, 1.18 to 7.49).
ConclusionThe present study demonstrates that the combination of TRAP1 and ERCC1 expressionpredicts the survival of metastatic CRC patients who were treated with oxaliplatin/5-fluorouracil.
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참고문헌 (23)
참고문헌 신청
Arnould S / 2003 / Cellular determinants of oxaliplatin sensitivity in colon cancer cell lines / Eur J Cancer 39 : 112 ~ 119
Braun MS / 2008 / Predictive biomarkers of chemotherapy efficacy in colorectal cancer : results from the UK MRC FOCUS trial / J Clin Oncol 26 : 2690 ~ 2698
Costantino E / 2009 / TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells / Cancer
Felts SJ / 2000 / The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties / J Biol Chem 275 : 3305 ~ 3312
Holm B / 2009 / Different impact of excision repair cross-complementation group 1 on survival in male and female patients with inoperable non-small-cell lung cancer treated
Braun MS / 2008 / Predictive biomarkers of chemotherapy efficacy in colorectal cancer : results from the UK MRC FOCUS trial / J Clin Oncol 26 : 2690 ~ 2698
Costantino E / 2009 / TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells / Cancer
Felts SJ / 2000 / The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties / J Biol Chem 275 : 3305 ~ 3312
Holm B / 2009 / Different impact of excision repair cross-complementation group 1 on survival in male and female patients with inoperable non-small-cell lung cancer treated
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