지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 280 - 280 (1page)
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We express our thanks to Dr. Cavoli for interest in our case [1] and shared experience of your case. A 60-year-old female with Erdheim-Chester disease (ECD) suffered from azotemia with bilateral hydronephrosis within 2 years of initial diagnosis. Author regarded a metforminassociated lactic acidosis combined with azotemia as the cause of her presentations. Although nearly 10% of cases with metformin-associated lactic acidosis were met for all three criteria (i.e., arterial pH＜7.35, blood lactate＞5 mmol/L, and detectable plasma metformin concentration)[2], plasma metformin concentration was not given in this patient. In addition, fever, abdominal pain, and leukocytosis raised a possibility of urinary tract infection accompanied by azotemia.
Regardless of causality, a wait-and-see policy was possible after the correction of azotemia in this patient. Similarly, our patient did not any specific treatment for ECD until August 2012 (more than 4 years from initial detection of left renal mass) and did not any genito-urinary symptoms [3]. Therefore, a wait-and-see policy might be acceptable for asymptomatic ECD patients. Considering that interferon-α appeared to be effective against bilateral hydronephrosis [4], its response might be important to design a treatment strategy in this patient. Recently, 13(54%) of 24 ECD patients harbored BRAF V600E mutation [5] and the identification of BRAF V600E mutation would provide a theoretical rationale for the use of BRAF inhibitors in patients with BRAF V600E-positive ECD with any symptoms or disease progression.
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참고문헌 (5)
참고문헌 신청
Gioacchino Li Cavoli / 2012 / Commentary on “A Case of Erdheim-Chester Disease with Asymptomatic Renal Involvement” / Cancer Research and Treatment 44 (4) : 279 ~ 279
Haroche J / 2006 / Variability in the efficacy of interferon-alpha in Erdheim-Chester disease by patient and site of involvement : results in eight patients / Arthritis Rheum
Haroche J / 2012 / High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses / Blood 120 : 2700 ~ 2703
Hyun Jung Lee / 2012 / A Case of Erdheim-Chester Disease with Asymptomatic Renal Involvement / Cancer Research and Treatment 44 (2) : 146 ~ 150
Kajbaf F / / The criteria for metformin-associated lactic acidosis: the quality of reporting in a large pharmacovigilance database
Haroche J / 2006 / Variability in the efficacy of interferon-alpha in Erdheim-Chester disease by patient and site of involvement : results in eight patients / Arthritis Rheum
Haroche J / 2012 / High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses / Blood 120 : 2700 ~ 2703
Hyun Jung Lee / 2012 / A Case of Erdheim-Chester Disease with Asymptomatic Renal Involvement / Cancer Research and Treatment 44 (2) : 146 ~ 150
Kajbaf F / / The criteria for metformin-associated lactic acidosis: the quality of reporting in a large pharmacovigilance database
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