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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 354 - 359 (6page)
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초록· 키워드
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Purpose: Capecitabine is an attractive oral chemotherapeutic agent that has a radiosensitizing effect and tumor-selectivity. This study was performed to evaluate the efficacy and toxicity of preoperative chemoradiation therapy, when used with oral capecitabine, for locally advanced rectal cancer. Materials and Methods: A prospective phase II trial of preoperative chemoradiation for locally advanced adenocarcinomas of the lower two-thirds of the rectum was conducted. A radiation dose of 50 Gy over five weeks and a daily dose of 1650 mg/m2 capecitabine in two potions was administered during the entire course of radiation therapy. Surgery was performed with standardized total mesorectal excision four to six weeks after completion of the chemoradiation. Results: Between January 2002 and September 2003, 61 patients were enrolled onto this prospective phase II trial. The pretreatment clinical stages were T3 in 64% (n=39), T4 in 36% (n=22) and N1-2 in 82% (n=50) of these patients. Fifty-six (92%) patients completed the chemoradiation as initially planned and a complete resection performed in 58 (95%). Down-staging was observed in 45 patients (74%) and a pathologic complete response in 6 (10%). Among the 37 patients with tumors located within 5 cm from the anal verge on colonoscopy, 27 (73%) underwent a sphincter-preserving procedure. No grade 3 and 4 proctitis or hematological toxicities were observed. Conclusion: Preoperative chemoradiation therapy with capecitabine achieved encouraging rates of tumor down- staging and sphincter preservation, with a low toxicity profile. This combined modality can be regarded as a safe and effective treatment for locally advanced rectal cancer.(Cancer Res Treat. 2004;36:354-359)
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
/ 1991 / Effective surgical adjuvant therapy forhigh-risk rectal carcinoma 324 : 709 ~ 15
/ 1994 / Improving adjuvant therapy forrectal cancer by combining protracted-infusion fluorouracil withradiation therapy after curative surgery 331 : 502 ~ 7
/ 1997 / Patient preferencesfor oral versus intravenous palliative chemotherapy 15 : 110 ~ 115
/ 1997 / Preoperative 5-FU,low-dose leucovorin,and radiationtherapy for locally advanced and unresectable rectalcancer 37 : 289 ~ 295
/ 1997 / Radiotherapy inaddition to radical surgery in rectal cancer evidence for adose-response effect favoring preoperative treatment 37 : 281 ~ 287
/ 1994 / Improving adjuvant therapy forrectal cancer by combining protracted-infusion fluorouracil withradiation therapy after curative surgery 331 : 502 ~ 7
/ 1997 / Patient preferencesfor oral versus intravenous palliative chemotherapy 15 : 110 ~ 115
/ 1997 / Preoperative 5-FU,low-dose leucovorin,and radiationtherapy for locally advanced and unresectable rectalcancer 37 : 289 ~ 295
/ 1997 / Radiotherapy inaddition to radical surgery in rectal cancer evidence for adose-response effect favoring preoperative treatment 37 : 281 ~ 287
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