지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 717 - 726 (10page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaElectroconvulsive therapy (ECT) is the most effective treatment for mood disorders. Accumulating evidence has suggested the important role of circadian genes in mood disorders. However, the effects of ECT on circadian genes have not been systemically investigated. MethodsaaWe examined the expression and daily oscillation of major circadian genes in the rat frontal cortex after electroconvulsive seizure (ECS). ResultsaaFirstly, mRNA and protein level were investigated at 24 hr after single ECS (E1X) and repeated ECS treatements for 10 days (E10X), which showed more remarkable changes after E10X than E1X. mRNA expression of Rorα, Bmal1, Clock, Per1, and Cry1 was decreased, while Rev-erbα expression was increased at 24 hr after E10X compared to sham. The proteins showed similar pattern of changes. Next, the effects on oscillation and rhythm properties (mesor, amplitude, and acrophase) were examined, which also showed more prominent changes after E10X than E1X. After E10X, mesor of Rorα, Bmal1, and Cry1 was reduced, and that of Rev-erbα was increased. Five genes, Rev-erbα, Bmal1, Per1, Per2, and Cry2, showed earlier acrophase after E10X. ConclusionaaThe findings suggest that repeated ECS induces reduced expression and phase advance of major circadian genes in the in vivo rat frontal cortex.
목차
등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
Boivin DB / 2000 / Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders / J Psychiatry Neurosci 25:446~458
Kapczinski F / 2011 / Sleep and circadian rhythm disturbances in bipolar disorder: an urgent need for objective assessment and systematic follow-up / J Clin Psychiatry 72:724
Landgraf D / 2014 / Circadian clock and stress interactions in the molecular biology of psychiatric disorders / Curr Psychiatry Rep 16:483
Partonen T / 2012 / Clock gene variants in mood and anxiety disorders / J Neural Transm (Vienna) 119:1133~1145
Mansour HA / 2009 / Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia / Bipolar Disord 11:701~710
Kapczinski F / 2011 / Sleep and circadian rhythm disturbances in bipolar disorder: an urgent need for objective assessment and systematic follow-up / J Clin Psychiatry 72:724
Landgraf D / 2014 / Circadian clock and stress interactions in the molecular biology of psychiatric disorders / Curr Psychiatry Rep 16:483
Partonen T / 2012 / Clock gene variants in mood and anxiety disorders / J Neural Transm (Vienna) 119:1133~1145
Mansour HA / 2009 / Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia / Bipolar Disord 11:701~710
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