지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 391 - 399 (9page)
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초록· 키워드
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Objective To assess the relative severity of nausea in patients from Korea with major depressive disorder (MDD) who were treated with duloxetine at low (30 mg) or high (60 mg) doses, with or without food, for the first week of an 8 week treatment.
Methods Adult patients (n=249), with MDD and a 17-item Hamilton Rating Scale for Depression (HAMD17) score of ≥15, received openlabel once daily duloxetine. At Week 0, patients were randomized to 4 groups: 30 mg with food (n=63), 60 mg with food (n=59), 30 mg without food (n=64), and 60 mg without food (n=63). At Week 1, all patients switched to duloxetine 60 mg for 7 weeks. The primary outcome measure was item 112 (nausea) of the Association for Methodology and Documentation in Psychiatry adverse event scale. Effectiveness was assessed by change in HAMD17 total score.
Results Overall, 94.4% (235/249) of patients completed Week 1 and 55.0% (137/249) of patients completed the study. For Week 1, nausea was significantly less severe for patients who received 30 mg compared with 60 mg duloxetine (p=0.003), regardless of food intake.
In all groups, nausea severity was highest at Week 1 and declined throughout the study. HAMD17 score was reduced in all groups and the most common adverse event reported was nausea (145/249; 58.2%).
Conclusion To minimize nausea, Korean patients with MDD who require duloxetine treatment could be given 30 mg once daily, regardless of food, for the first week followed by 60 mg once daily for the course of therapy.
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참고문헌 (15)
참고문헌 신청
Brunton S. / 2010 / Profile of adverse events with duloxetine treatment: a pooled analysis of placebo-controlled studies / Drug Saf 33 : 393 ~ 407
Chen PY. / 2009 / Biological variations in depression and anxiety between East and West / CNS Neurosci Ther 15 : 283 ~ 294
Detke MJ. / 2002 / Duloxetine60 mg once daily dosing versus placebo in the acute treatment ofmajor depression / J Psychiatr Res 36 : 383 ~ 390
Dunner DL. / 2005 / Clinical consequences of initial duloxetine dosing strategies: comparison of 30 and 60 mg starting doses / Curr Ther Res 66 : 522 ~ 540
Epstein WV. / 1996 / Expectation bias in rheumatoid arthritis. The anti-CD4 monoclonal antibody experience / Arthritis Rheum 39 : 1773 ~ 1780
Chen PY. / 2009 / Biological variations in depression and anxiety between East and West / CNS Neurosci Ther 15 : 283 ~ 294
Detke MJ. / 2002 / Duloxetine60 mg once daily dosing versus placebo in the acute treatment ofmajor depression / J Psychiatr Res 36 : 383 ~ 390
Dunner DL. / 2005 / Clinical consequences of initial duloxetine dosing strategies: comparison of 30 and 60 mg starting doses / Curr Ther Res 66 : 522 ~ 540
Epstein WV. / 1996 / Expectation bias in rheumatoid arthritis. The anti-CD4 monoclonal antibody experience / Arthritis Rheum 39 : 1773 ~ 1780
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