지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 400 - 407 (8page)
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초록· 키워드
오류제보하기
Objective 1) To investigate the relationship between NrCAM polymorphisms and methamphetamine abuse in an ethnically homogenous Korean population. 2) To further support our findings by investigating the association among NrCAM gene variants, certain personality traits, and addictive symptoms of methamphetamine abusers.
Methods Thirty-seven male methamphetamine abusers (age=43.3±7.8) and30 non-users (16 men, 14 women; age=59.8±10.4) were recruited. Ten single nucleotide polymorphisms (SNPs) in the NrCAM gene were assayed to compare genotype distributions between the 2 groups. Personality characteristics were measured using the Temperament and Character Inventory (TCI) and the NEO Personality Inventory, Revised (NEO PI-R). Addictive symptoms were assessed using the Diagnostic Interview for Genetic Studies (DIGS) and reviews of the subject’s medical records.
ResultsaaAmong the 10 SNPs in the NrCAM gene, the frequency of the TA genotype at rs1990162 was significantly lower in methamphetamine abusers compared to non-users (p=0.042). In the 3 NrCAM gene SNPs (rs381318, rs2072546, and rs6954366), the distribution of genotypes and alleles were significantly associated with some traits in the TCI and NEO PI-R. Genotypes and alleles at 5 gene SNPs (rs2142325, rs381318, rs1269621, rs1269634, and rs1990162) were associated with certain addictive symptom dimensions in the patients.
Conclusion These findings support the idea that NrCAM is associated with genetic susceptibility of methamphetamine abuse and is also associated with certain personality characteristics that may increase disturbed addictive behavior.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
American Psychiatric Association / 1996 / Diagnostic and Statistical Manual of Mental Disorders / American Psychiatric Publishing
Chung H. / 2004 / Recent trends of drug abuse and drug-associated deaths in Korea / Ann N Y Acad Sci 1025 : 458 ~ 464
Cloni
Cloninger CR. / 2000 / A practical way to diagnosis personality disorder: a proposal / J Pers Disord 14 : 99 ~ 108
Comings DE. / 2000 / Molecular heterosis: a review / Mol Genet Metab 71 : 19 ~ 31
Chung H. / 2004 / Recent trends of drug abuse and drug-associated deaths in Korea / Ann N Y Acad Sci 1025 : 458 ~ 464
Cloni
Cloninger CR. / 2000 / A practical way to diagnosis personality disorder: a proposal / J Pers Disord 14 : 99 ~ 108
Comings DE. / 2000 / Molecular heterosis: a review / Mol Genet Metab 71 : 19 ~ 31
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