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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 78 - 84 (7page)
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초록· 키워드
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Objective: Treatment of bipolar patients is often complicated by metabolic abnormalities such as obesity, diabetes, and dyslipidemia. We therefore evaluated the prevalence of these abnormalities and their correlates, in bipolar I patients, at the time of commencement of pharmacological treatment for acute mood episodes.
Methods: The study cohort consisted of 184 bipolar I patients hospitalized for treatment of acute mood episodes. Socio-demographic and clinical variables were noted and metabolic parameters, including body mass index, fasting plasma glucose, fasting total cholesterol, and current treatment(s) for diabetes and/or dyslipidemia were measured before initiating medication(s).
ResultsaaFifty-six (30.4%) subjects met our criteria for obesity; 80 (43.5%) had hyperglycemia, with 8 (4.3%) receiving anti-diabetic medication; and 38 (20.7%) had hypercholesterolemia, with 2 (1.1%) receiving cholesterol-lowering agents. We found that male sex (χ2=5.359, p=0.021), depressed or mixed state versus manic state (χ2=4.302, p=0.038), and duration of illness (t=2.756, p=0.006) were significantly associated with obesity. Older age (t= 3.668, p<0.001), later age of disease onset (t=2.271, p=0.024), and lower level of educational attainment (β=-0.531, p=0.001) were associated with hyperglycemia.
Conclusion: Our finding that metabolic abnormalities are prevalent when initiating acute pharmacological treatment in bipolar I patients indicates that these factors should be integrated into treatment plans at the onset of disease management.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Atmaca M / 2002 / Serum leptin and cholesterol levels in patients with bipolar disorder / Neuropsychobiology 46 : 176 ~ 179
Cardenas J / 2008 / Modal subcomponents of metabolic syndrome in patients with bipolar disorder / J Affect Disord 106 : 91 ~ 97
Cassidy F / 1999 / Elevated frequency of diabetes mellitus in hospitalized manic-depressive patients / Am J Psychiatry 156 : 1417 ~ 1420
Elmslie JL / 2000 / Prevalence of overweight and obesity in bipolar patients / J Clin Psychiatry 61 : 179 ~ 184
Elmslie JL / 2001 / Determinants of overweight and obesity in patients with bipolar disorder / J Clin Psychiatry 62 : 486 ~ 491
Cardenas J / 2008 / Modal subcomponents of metabolic syndrome in patients with bipolar disorder / J Affect Disord 106 : 91 ~ 97
Cassidy F / 1999 / Elevated frequency of diabetes mellitus in hospitalized manic-depressive patients / Am J Psychiatry 156 : 1417 ~ 1420
Elmslie JL / 2000 / Prevalence of overweight and obesity in bipolar patients / J Clin Psychiatry 61 : 179 ~ 184
Elmslie JL / 2001 / Determinants of overweight and obesity in patients with bipolar disorder / J Clin Psychiatry 62 : 486 ~ 491
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