지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives Thalamic structural changes were implicated in the pathophysiology of schizophrenia by some studies. So, we investigated the differences in thalamic volumes between previously untreated patients with first-episode schizophrenia and controls.
Methods Thalamic volumes of 24 subjects with schizophrenia and 24 controls were measured from their T1-weighted coronal magnetic resonance images using manual tracing. The thalamus was further segmented into regions that roughly reflected individual thalamic nuclei.
Results Comparing to the controls, significantly smaller volumes were found in the left posterior subdivision of thalamus in patient group. Tendency of volume differences were also seen in right posterior subdivision of thalamus in patient group. These regions primarily comprised the pulvinar, a thalamic nucleus thought to be an important component of aberrant circuitry in schizophrenia.
Conclusion Our findings suggest the possibility of a volumetric alteration of the thalamus in patients with first-episode schizophrenia.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Arciniegas D / 1999 / The thalamus and the schizophrenia phenotype: failure to replicate reduced volume / Biol Psychiatry 45:1329~1335
Scherk H / 2006 / Effects of antipsychotics on brain structure / Curr Opin Psychiatry 19:145~150
Jayakumar PN / 2005 / Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 29:587~591
Pakkenberg B / 1992 / The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics / Schizophr Res 7:95~100
Kemether EM / 2003 / Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia / Arch Gen Psychiatry 60:983~991
Scherk H / 2006 / Effects of antipsychotics on brain structure / Curr Opin Psychiatry 19:145~150
Jayakumar PN / 2005 / Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 29:587~591
Pakkenberg B / 1992 / The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics / Schizophr Res 7:95~100
Kemether EM / 2003 / Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia / Arch Gen Psychiatry 60:983~991
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