지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 844 - 850 (7page)
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초록· 키워드
오류제보하기
Objective: The anti-epileptogenic drug levetiracetam has anticonvulsant and anti-epileptogenesis effects. Synergy between cell death and inflammation can lead to increased levels of apoptosis inhibitory factors and brain-derived neurotrophic factor, aberrant neurogenesis and extended axon sprouting. Once hyperexcitation of the neural network occurs, spontaneous seizures or epileptogenesis develops. This study investigated whether the anti-epileptogenic effect of levetiracetam is due to its alternate apoptotic activity.
Methods: Adult male Noda epileptic rats were treated with levetiracetam or vehicle control for two weeks. mRNA quantification of Bax, Bcl-2 and GAPDH expression were performed from prefrontal cortex and hippocampus tissue samples.
Results: The levetiracetam-treated group showed a significant increase of Bax/Bcl-2 mRNA expression ratio in the prefrontal cortex than the control group, but no change in the Bax/Bcl-2 mRNA expression ratio in hippocampus.
Conclusion: Idiopathic generalized epilepsy including childhood absence epilepsy develop at childhood and recover spontaneously during adolescence. The aberrant neural excitable network is pruned by a neural-maturing action. This study suggests the mechanism of acquired anti-epileptogenesis by levetiracetam treatment may be similar to spontaneous recovery of idiopathic generalized epilepsy during adolescence.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
[학술지(정
Armijo JA / 2005 / Ion channels and epilepsy / Curr Pharm Des 11 : 1975 ~ 2003
Bozzi Y / 2011 / Cell signaling underlying epileptic behavior / Front Behav Neurosci 5 : 45 ~
Eisenstein M / 2011 / Genetics: finding risk factors / Nature 475 : S20 ~ S22
Engel T / 2009 / Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? / Int J Physiol Pathophysiol Pharmacol 1 : 97 ~ 115
Armijo JA / 2005 / Ion channels and epilepsy / Curr Pharm Des 11 : 1975 ~ 2003
Bozzi Y / 2011 / Cell signaling underlying epileptic behavior / Front Behav Neurosci 5 : 45 ~
Eisenstein M / 2011 / Genetics: finding risk factors / Nature 475 : S20 ~ S22
Engel T / 2009 / Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? / Int J Physiol Pathophysiol Pharmacol 1 : 97 ~ 115
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