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Objective We aimed to investigate the neurocognitive and behavioral endophenotypes of premorbid mood disorder. We compared intelligence,neuropsychological functioning, and behavioral problems among three groups: 1) a high-risk group [attention-deficit hyperactivitydisorder (ADHD) children of parents with a history of a mood disorder], 2) a low-risk group (ADHD children of parents without ahistory of a mood disorder), and 3) normal comparison subjects. Methods We used the Korean Educational Development Institute Wechsler Intelligence Scale for Children-Revised (KEDI-WISC-R),the Stroop Color Word Interference Test (Stroop), the Wisconsin Card Sorting Test (WCST), and the Rey-Osterrieth Complex Figure Test(RCFT) as neurocognitive measures, and we used the Child Behavior Checklist (CBCL) as a behavioral measure. Performance on theseneuropsychological tests and score on the CBCL of 18 high-risk children were compared to those of 20 low-risk children and 24 healthychildren. We also assessed the children’s current mood state and familial functioning to control for the confounding effects of these variables. Results Compared to low-risk and healthy children, high-risk children were impaired on the Picture Completion and Stroop Wordsubtest and showed higher scores on the CBCL subscales representing internalizing symptoms. These significant group differences persistedeven after adjustment for the children’s current mood state and familial functioning. Conclusion Neuropsychological deficits in the offspring of parents with a mood disorder may be associated with the current moodstate rather than with innate characteristics, while their internalizing symptoms may partially stem from innate characteristics that are endophenotypesof a premorbid mood disorder.

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