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We aimed to compare the recommendations of the Korean Medication Algorithm Project for Depressive Disorder 2012 (KMAP-DD2012) with other recently published treatment guidelines for depressive disorder. We reviewed a total of five recently published globaltreatment guidelines and compared each treatment recommendation of the KMAP-DD 2012 with those in other guidelines. For initialtreatment recommendations, there were no significant major differences across guidelines. However, in the case of nonresponse or incompleteresponse to initial treatment, the second recommended treatment step varied across guidelines. For maintenance therapy,medication dose and duration differed among treatment guidelines. Further, there were several discrepancies in the recommendationsfor each subtype of depressive disorder across guidelines. For treatment in special populations, there were no significant differences inoverall recommendations. This comparison identifies that, by and large, the treatment recommendations of the KMAP-DD 2012 aresimilar to those of other treatment guidelines and reflect current changes in prescription pattern for depression based on accumulatedresearch data. Further studies will be needed to address several issues identified in our review.

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