지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 76 - 83 (8page)
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초록· 키워드
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Objective The etiology of attention deficit hyperactivity disorder (ADHD) has not been entirely clarified yet. Structural and metabolicdifferences at the prefrontal striatal cerebellary system and the interaction of gene and environment are the main factors that thought toplay roles in the etiology. Genetic investigations are performed especially about the dopamine pathways and receptors. In this study; itwas aimed to investigate the association of the synaptobrevin-2 (VAMP-2) gene Ins/Del polymorphism and syntaxin 1A gene intron7 polymorphism, which take place in encoding presynaptic protein, with adult ADHD.
Methods One hundred thirty-nine patients, having ADHD aging between 18 and 60 years and 106 healthy people as controls were includedinto the study. DNA samples were extracted from whole blood and genetic analysis were performed.
ResultsaaA significant difference was determined between ADHD and VAMP-2 Ins/Del polymorphism and syntaxin 1A intron 7 polymorphismaccording to the control group. These polymorphisms were found not to be associated with subtypes of ADHD.
Conclusion It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Mick E / 2008 / Genetics of attention deficit hyper-activity disorder / Child Adolesc Psychiatr Clin N Am 17:261~284
Rutter M / 2002 / Gene-environment interplay in relation to emotional and behavioral disturbance / Annu Rev Psychol 53:463~490
Zoroğlu SS / 2002 / Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder / Neuropsychobiology 45:176~181
Comings DE / 2000 / Comparison of the role of dopamine, serotonin and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes / Clin Genet 57:178~196
Wilson MC / 2000 / Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder / Neurosci Biobehav Rev 24:51~57
Rutter M / 2002 / Gene-environment interplay in relation to emotional and behavioral disturbance / Annu Rev Psychol 53:463~490
Zoroğlu SS / 2002 / Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder / Neuropsychobiology 45:176~181
Comings DE / 2000 / Comparison of the role of dopamine, serotonin and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes / Clin Genet 57:178~196
Wilson MC / 2000 / Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder / Neurosci Biobehav Rev 24:51~57
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