지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 225 - 232 (8page)
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초록· 키워드
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Numerous hypotheses have been put forth over the years to explain the development of bipolar disorder. Of these, circadian rhythm hypotheses have gained much importance of late. While the hypothalamus-pituitary-adrenal (HPA) axis hyperactivation hypothesis and the monoamine hypothesis somewhat explain the pathogenic mechanism of depression, they do not provide an explanation for the development of mania/hypomania. Interestingly, all patients with bipolar disorder display significant disruption of circadian rhythms and sleep/wake cycles throughout their mood cycles. Indeed, mice carrying the Clock gene mutation exhibit an overall behavioral profile that is similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, and lower anxiety. It was recently reported that monoamine signaling is in fact regulated by the circadian system. Thus, circadian rhythm instability, imposed on the dysregulation of HPA axis and monoamine system, may in turn increase individual susceptibility for switching from depression to mania/hypomania. In addition to addressing the pathophysiologic mechanism underlying the manic switch, circadian rhythm hypotheses can explain other bipolar disorder-related phenomena such as treatment resistant depression and mixed features.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Abe M / 2000 / Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons / Neuroreport 11 : 3261 ~ 3264
Akiskal HS / 2000 / Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders / J Affect Disord 59 (Suppl1) : S5 ~ S3
Bao AM / 2008 / The stress system in depression and neurodegeneration: focus on the human hypothalamus / Brain Res Rev 57 : 531 ~ 553
Bunney BG / 2013 / Mechanisms of rapid antidepressant effects of sleep deprivation therapy: clock genes and circadian rhythms / Biol Psychiatry 73 : 1164 ~ 1171
Capsi A / 2003 / Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene / Science 301 : 386 ~ 389
Akiskal HS / 2000 / Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders / J Affect Disord 59 (Suppl1) : S5 ~ S3
Bao AM / 2008 / The stress system in depression and neurodegeneration: focus on the human hypothalamus / Brain Res Rev 57 : 531 ~ 553
Bunney BG / 2013 / Mechanisms of rapid antidepressant effects of sleep deprivation therapy: clock genes and circadian rhythms / Biol Psychiatry 73 : 1164 ~ 1171
Capsi A / 2003 / Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene / Science 301 : 386 ~ 389
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