지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 191 - 194 (4page)
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초록· 키워드
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Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Three single nucleotide polymorphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. There were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Akyol O. / 2005 / Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 29 : 123 ~ 131
Chen CH. / 1997 / Association of TaqI A polymorphism of dopamine D2 receptor gene and tardive dyskinesia in schizophrenia / Biol Psychiatry 41 : 827 ~ 829
Correll CU. / 2004 / Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies / Am J Psychiatry 161 : 414 ~
Correll CU. / 2008 / Tardive dyskinesia and new antipsychotics / Curr Opin Psychiatry 21 : 151 ~ 156
De Keyser J. / 1991 / Excitotoxic mechanisms may be involved in the pathophysiology of tardive dyskinesia / Clin Neuropharmacol 14 : 562 ~ 565
Chen CH. / 1997 / Association of TaqI A polymorphism of dopamine D2 receptor gene and tardive dyskinesia in schizophrenia / Biol Psychiatry 41 : 827 ~ 829
Correll CU. / 2004 / Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies / Am J Psychiatry 161 : 414 ~
Correll CU. / 2008 / Tardive dyskinesia and new antipsychotics / Curr Opin Psychiatry 21 : 151 ~ 156
De Keyser J. / 1991 / Excitotoxic mechanisms may be involved in the pathophysiology of tardive dyskinesia / Clin Neuropharmacol 14 : 562 ~ 565
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