지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 245 - 249 (5page)
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초록· 키워드
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Objective Obstructive sleep apnea syndrome (OSAS) has been associated with cardiovascular complications and insulin resistance has been implicated in the pathogenesis and progression of atherosclerosis. We investigated whether insulin resistance is associated with OSAS independent of obesity.
Methods A total of 183 male patients with OSAS and 52 healthy controls were assessed by nocturnal polysomnography (NPSG). After NPSG, serum concentrations of total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, glucose and insulin were measured. Insulin resistance was determined by calculating the homeostasis model assessment for insulin resistance (HOMA-IR).
Results Subjects were divided into normal control, mild-to-moderate OSA group (n=96) and severe OSA group (n=87). There were no significant differences among groups in age, body mass index (BMI), neck circumference or waist circumference. Serum concentrations of total cholesterol, LDL cholesterol, triglycerides, glucose, insulin and HOMA-IR scores of normal controls did not differ from those of the mild-to-moderate or severe OSAS groups. HOMA-IR significantly correlated with anthropometric variables, oxygen desaturation index, triglyceride and LDL cholesterol. Stepwise multiple linear regression analysis showed that waist circumference (β=0.35) and triglycerides (β=0.27) were significant determinants of HOMA-IR (adjusted R2=20%, p<0.01).
Conclusion Insulin resistance was related to obesity itself rather than OSAS severity or nocturnal hypoxemia-related variables. In preventing cardiovascular complications in OSAS patients, weight reduction should be considered.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] -
Andreas S / 1996 / Prevalence of obstructive sleep apnoea in patients with coronary artery disease / Coron Artery Dis 7 : 541 ~ 545
Ascaso JF / 2003 / Abdominal obesity, insulin resistance, and metabolic syndrome in a southern European population / Eur J Intern Med 14 : 101 ~ 106
Gould GA / 1988 / The sleep hypopnea syndrome / Am Rev Respir Dis 137 : 895 ~ 898
Haffner SM / 2000 / Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronar
Andreas S / 1996 / Prevalence of obstructive sleep apnoea in patients with coronary artery disease / Coron Artery Dis 7 : 541 ~ 545
Ascaso JF / 2003 / Abdominal obesity, insulin resistance, and metabolic syndrome in a southern European population / Eur J Intern Med 14 : 101 ~ 106
Gould GA / 1988 / The sleep hypopnea syndrome / Am Rev Respir Dis 137 : 895 ~ 898
Haffner SM / 2000 / Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronar
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