지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 262 - 268 (7page)
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초록· 키워드
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Objective Genetic variation in the serotonin-2C receptor encoded by the HTR2C gene is one of the genetic determinants of antipsychotic-induced weight gain. Peroxisome proliferator-activated receptors are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. In this cross-sectional study, we investigated whether HTR2C-759C/T, HTR2C-697G/C, PPARα V227A, and PPARγ 161C/T genotypes were associated with metabolic syndrome (MetS) in patients with schizophrenia taking clozapine.
Methods One hundred forty-six Korean patients using clozapine for more than one year were genotyped for the HTR2C-759C/T, HTR2C-697G/C, PPARα V227A, and PPARγ 161C/T polymorphisms, and their weight, waist circumference, blood pressure, triglycerides, high-density lipoprotein-cholesterol, total cholesterol, and glucose were measured. We used the criteria for MetS proposed by the National Cholesterol Education Program-adapted Adult Treatment Panel III.
Results The prevalence of MetS was 47.3% and was similar among men (49%) and women (42.9%). We found no significant differences between patients with and without MetS in terms of genotypes or allele frequencies. Logistic regression analyses also revealed no association between MetS and each genotype.
Conclusion We did not find significant associations between four polymorphisms (HTR2C-759C/T, HTR2C-697G/C, PPARα V227A, and PPARγ 161C/T) and MetS in patients with schizophrenia taking clozapine.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Allison DB / 1999 / Cappelleri JC, Infante MC et al. Antipsychotic-induced weight gain: a comprehensive research synthesis / Am J Psychiatry 156 : 1686 ~ 1696
Correll CU / 2007 / Balancing efficacy and safety in treatment with antipsychotics / CNS Spectr 12 (10) : 12 ~ 20
Ellingrod VL / 2005 / Weight gain associated with the-759C/T polymorphism of the 5HT2C receptor and olanzapine / Am J Med Genet B Neuropsychiatr Genet 134B : 76 ~ 78
Haffner SM / 1992 / Prospective analysis of the insulin-resistance syndrome (syndrome X) / Diabetes 41 : 715 ~ 722
Henderson DC / 2000 / Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study / Am J Psychiatry 157 : 975 ~ 981
Correll CU / 2007 / Balancing efficacy and safety in treatment with antipsychotics / CNS Spectr 12 (10) : 12 ~ 20
Ellingrod VL / 2005 / Weight gain associated with the-759C/T polymorphism of the 5HT2C receptor and olanzapine / Am J Med Genet B Neuropsychiatr Genet 134B : 76 ~ 78
Haffner SM / 1992 / Prospective analysis of the insulin-resistance syndrome (syndrome X) / Diabetes 41 : 715 ~ 722
Henderson DC / 2000 / Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study / Am J Psychiatry 157 : 975 ~ 981
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