지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 327 - 332 (6page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaPostoperative delirium (POD) is a highly prevalent complex neuropsychiatric syndrome in elderly patients. However, its pathophysiology is currently unknown. Early detection and prevention of POD is important; therefore, the aim of this study was to investigate the link between preoperative insulin growth factor 1 (IGF-1) levels in the serum and POD in the Chinese elderly patients.
MethodsaaOne hundred and three patients who were undergoing an orthopedic operation took part in the study. Preoperative serum IGF-1 levels were measured. POD was determined daily using the Confusion Assessment Method (CAM) and DSM-IV TR. Baseline serum IGF-1 levels were compared between patients who did and did not develop POD. Correlation coefficients were calculated to evaluate relationship between baseline characteristics and serum IGF-1 levels. The relationship between baseline biomarkers and delirium status was investigated using logistic regression analysis, adjusting for potential confounding variables.
ResultsaaTwenty-three patients developed POD. The POD group had lower MMSE scores and higher CCI scores and proportions of acute admission. Preoperative serum IGF-1 levels were correlated with MMSE scores and age (MMSE: r=0.230, p<0.05; age: r=-0.419, p<0.001). Baseline serum IGF-1 levels did not differ between patients who did and did not develop POD, even after adjusting for potential confounding factors, MMSE score, and age.
ConclusionaaNo association was found between preoperative IGF-1 levels and POD, suggesting that they are not direct biomarkers of the incidence of POD among the Chinese elderly population. Further research with larger sample sizes is warranted to clarify the relationship.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Amador LF / 2005 / Postoperative delirium in the older patient / J Am Coll Surg 200:767~773
Hyo Jin Lee / 2011 / Early Assessment of Delirium in Elderly Patients after Hip Surgery / PSYCHIATRY INVESTIGATION 8(4):340~347
Liang CK / 2014 / Interrelationship of postoperative delirium and cognitive impairment and their impact on the functional status in older patients undergoing orthopaedic surgery: a prospective cohort study / PLoS One 9:e110339
Yu KD / 2005 / Delirium in acute elderly care unit; prevalence, clinical characteristics, risk factors and prognostic significance / Psychiatry Investig 2:80~82
Chu CL / 2001 / Biomarkers of delirium: well evidenced or not? / J Clin Gerontol Geriatr 2:100~104
Hyo Jin Lee / 2011 / Early Assessment of Delirium in Elderly Patients after Hip Surgery / PSYCHIATRY INVESTIGATION 8(4):340~347
Liang CK / 2014 / Interrelationship of postoperative delirium and cognitive impairment and their impact on the functional status in older patients undergoing orthopaedic surgery: a prospective cohort study / PLoS One 9:e110339
Yu KD / 2005 / Delirium in acute elderly care unit; prevalence, clinical characteristics, risk factors and prognostic significance / Psychiatry Investig 2:80~82
Chu CL / 2001 / Biomarkers of delirium: well evidenced or not? / J Clin Gerontol Geriatr 2:100~104
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