지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 454 - 458 (5page)
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초록· 키워드
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Objective Repeated treatment with psychostimulants induces sensitization of the dopaminergic system in the brain. Dopaminergic sensitization has been proposed as a mechanism of psychosis. Although antipsychotics block the expression of sensitized behavior, they are ineffective for reversing the sensitized state. We investigated the effect of clozapine, haloperidol, and fluoxetine on the reversal of cocaine-induced behavioral sensitization.
Methods Male ICR mice were sensitized to cocaine with repeated treatment. Animals were then split into four groups, and each group was treated with vehicle or one of the above drugs for 5 days. After a 3-day drug washout, locomotor activity was assessed before and after a cocaine challenge.
Results Clozapine reversed the sensitized state, whereas haloperidol did not. Fluoxetine seemed to reverse the sensitization partially.
Conclusion We confirmed that D2 blockade was not effective for reversing sensitization. The reversal by clozapine is partially explained in terms of its strong 5-HT2 and weak D2 affinity. The partial reversal by fluoxetine seemed to be related to its serotonin-augmenting action.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ago Y / 2007 / Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice / Synapse 61 : 757 ~ 763
Andreassen OA / 1995 / The rat model of tardive dyskinesia:relationship between vacuous chewing movements and gross motor activity during acute and long-term haloperidol tre
Bersani G / 1991 / 5-HT2 receptor antagonism in dysthymic disorder: a double-blind placebo-controlled study with ritanserin / Acta Psychiatr Scand 83 : 244 ~ 248
Blier P / 2011 / Neurobiological bases and clinical aspects of the use of aripiprazole in treatment-resistant major depressive disorder / J Affect Disord 128 (Suppl 1) : S3
Casey DE / 2000 / Tardive dyskinesia: pathophysiology and animal models / J Clin Psychiatry 61 (Suppl 4) : 5 ~ 9
Andreassen OA / 1995 / The rat model of tardive dyskinesia:relationship between vacuous chewing movements and gross motor activity during acute and long-term haloperidol tre
Bersani G / 1991 / 5-HT2 receptor antagonism in dysthymic disorder: a double-blind placebo-controlled study with ritanserin / Acta Psychiatr Scand 83 : 244 ~ 248
Blier P / 2011 / Neurobiological bases and clinical aspects of the use of aripiprazole in treatment-resistant major depressive disorder / J Affect Disord 128 (Suppl 1) : S3
Casey DE / 2000 / Tardive dyskinesia: pathophysiology and animal models / J Clin Psychiatry 61 (Suppl 4) : 5 ~ 9
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