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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 9 - 19 (11page)
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Classical multiple sclerosis (MS) treatments using first-line injectable drugs, although widelyapplied, remain a major concern in terms of therapeutic adherence and efficacy. New oral drugsrecently approved for MS treatment represent significant advances in therapy. The oral route ofadministration clearly promotes patient satisfaction and increases therapeutic compliance.
However, these drugs may also have safety and tolerability issues, and a thorough analysis ofthe risks and benefits is required. Three oral drugs have been approved by regulatory agenciesfor MS treatment: fingolimod, teriflunomide, and dimethyl fumarate. This article reviews themechanisms of action, safety, and efficacy of these drugs and two other drugs that have yieldedpositive results in phase III trials: cladribine and laquinimod.
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참고문헌 (25)
참고문헌 신청
Brinkmann V / 2002 / The immune modulator FTY720 targets sphingosine 1-phosphate receptors / J Biol Chem 277 : 21453 ~ 21457
Brinkmann V / 2004 / FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function / Am J Transplant 4 : 1019 ~ 1025
Calabresi PA / 2014 / Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled
Cohen JA / 2010 / Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis / N Engl J Med 362 : 402 ~ 415
Cohen JA / 2011 / Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis / Ann Neurol 69 : 759 ~ 777
Brinkmann V / 2004 / FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function / Am J Transplant 4 : 1019 ~ 1025
Calabresi PA / 2014 / Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled
Cohen JA / 2010 / Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis / N Engl J Med 362 : 402 ~ 415
Cohen JA / 2011 / Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis / Ann Neurol 69 : 759 ~ 777
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