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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제9권 제3호
발행연도
2013.1
수록면
157 - 164 (8page)

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Background and Purpose It is recommended that Botox be used within 5 hours of reconstitution, which results in substantial quantities being discarded. This is not only uneconomic, but also inconvenient for treating patients. The aim of this study was to determine the potencies of Botox used within 2 hours of reconstitution with unpreserved saline, the same Botox refrigerated (at +4ºC) 72 hours after reconstitution, and during the next 4 consecutive weeks (weeks 1, 2,3, and 4). This comparison was used to determine the length of refrigeration time during which reconstituted Botox will maintain the same efficacy as freshly reconstituted toxin. Methods Individual paralysis rates in the extensor digitorum brevis (EDB) compound muscle action potential (CMAP) amplitude and area were measured 1 week after injecting fresh reconstituted 2.5 MU of Botox on one side of the foot, and when the same quantity of Botox that had been refrigerated for a designated time (i.e., 72 h, or 1, 2, 3, or 4 weeks) into the other side of the foot. The EDB CMAP amplitude and area at 12 and 16 weeks postinjection were also measured to compare the efficacy durations in all five comparative groups. Results Ninety-four volunteers were divided into five groups according to the refrigerator storage time of the second Botox injection. The paralysis of the EDBs was significant for each injection of Botox, both fresh and refrigerated, with no statistically significant differences between them, regardless of the refrigeration time. There was a tendency toward increased CMAP amplitude and area at 12 or 16 weeks postinjection (p<0.0001). The duration of effective muscle paralysis did not differ significantly throughout the 16-week follow-up period between all five groups. Conclusions The potency of reconstituted Botox is not degraded by subsequent refrigeration for 4 weeks. However, there are definite concerns regarding its sterility, and hence its safety,since multiple withdrawals from the same vial over long periods can introduce bacterial contamination.
#botox #potency #refrigeration.

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참고문헌 (23)

참고문헌 신청
Ahn KY / 2000 / Botulinum toxin A for the treatment of facial hyperkinetic wrinkle lines in Koreans / Plastic and Reconstructive Surgery 105 : 778 ~ 784 google schola Blasi J / 1993 / Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP- 25 / Nature 365 : 160 ~ 163 google schola Brin MF / 1997 / Botulinum toxin: new and expanded indications / European Journal of Neurology 4 : S59 ~ S65 google schola Brin MF / 2002 / Botulinum toxin type A for pain and headache, In Scientific and Therapeutic Aspects of Botulinum Toxin / Lippincott Williams & Wilkins google schola Carruthers J / 2001 / Botulinum toxin (botox) chemodenervation for facial rejuvenation / Facial Plastic Surgery Clinics of North America 9 : 197 ~ 204 google schola

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