지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 186 - 191 (6page)
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초록· 키워드
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Background and Purpose Sudden cardiac death is one of the leading causes of death in patients with myotonic dystrophy type 1 (DM1). It has been proposed that a prolonged QT interval is associated with sudden cardiac death in several neurological diseases, including multiple system atrophy, idiopathic Parkinson’s disease, and diabetic autonomic neuropathy. However, analyses of the corrected QT (QTc) interval in DM1 patients are rare in the literature. The purposes of this study were to determine the association between the QT interval and DM1, and the affecting factors.
Methods Thirty-nine patients diagnosed with DM1 through genetic testing were enrolled. The QTc interval (calculated using Bazett’s formula: QTc=QT/√RR) was compared between these patients and 39 normal healthy controls. The clinical and laboratory factors affecting QTc interval in the patient group were investigated.
Results The QTc interval was significantly longer in the DM1 group (411.2±44.7 msec, mean±SD) than in the normal control group (355.6±20.6 msec). Intragroup analysis revealed that a prolonged QTc interval in DM1 patients was associated with being female and older, having a longer disease duration, and exhibiting abnormal electrocardiography findings.
Conclusions The higher incidence of sudden cardiac death in the DM1 population is associated with the observed prolonged QTc interval in those patients.
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참고문헌 (24)
참고문헌 신청
Ashizawa T / 1992 / Anticipation in myotonic dystrophy. I. Statistical verification based on clinical and haplotype findings / Neurology 42 : 1871 ~ 1877
Aslanidis C / 1992 / Cloning of the essential myotonic dystrophy region and mapping of the putative defect / Nature 355 : 548 ~ 551
Breton R / 2009 / Usefulness of clinical and electrocardiographic data for predicting adverse cardiac events in patients with myotonic dystrophy / Canadian Journal of Cardio
Deguchi K / 2002 / Abnormalities of rate-corrected QT intervals in Parkinson’s disease- a comparison with multiple system atrophy and progressive supranuclear palsy / Journ
Finsterer J / 2001 / Relation of cardiac abnormalities and CTG-repeat size in myotonic dystrophy / Clinical Genetics 59 : 350 ~ 355
Aslanidis C / 1992 / Cloning of the essential myotonic dystrophy region and mapping of the putative defect / Nature 355 : 548 ~ 551
Breton R / 2009 / Usefulness of clinical and electrocardiographic data for predicting adverse cardiac events in patients with myotonic dystrophy / Canadian Journal of Cardio
Deguchi K / 2002 / Abnormalities of rate-corrected QT intervals in Parkinson’s disease- a comparison with multiple system atrophy and progressive supranuclear palsy / Journ
Finsterer J / 2001 / Relation of cardiac abnormalities and CTG-repeat size in myotonic dystrophy / Clinical Genetics 59 : 350 ~ 355
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