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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 79 - 81 (3page)
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초록· 키워드
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Background and purpose: Neuropathological studies have demonstrated that multiple system atrophy (MSA) produces selective atrophy of the putamen with sparing of the caudate nucleus, while both structures are spared in idiopathic Parkinson’s disease (PD). In this study we evaluated the clinical efficacy of using putaminal atrophy in brain MRI to differentiate MSA and PD.
Methods: We measured the putamen/caudate volume ratio on brain MRI in 24 patients with MSA and 21 patients with PD. Two clinicians who were blinded to the patients’ diagnoses and to each other’s assessments measured the volume ratio using a computer program.
Results: The measured volume ratios of the two investigators were highly correlated (r=0.72, p<0.0001). The volume ratio was significantly lower in MSA (1.29±0.28) than PD (1.91±0.29, p<0.0001). Setting an arbitrary cutoff ratio of 1.6 resulted in about 90% of patients with MSA falling into the group with a lower ratio, whereas more than 80% of patients with PD belonged to the other group.
Conclusions: The present results demonstrate that putaminal atrophy in MSA as measured on brain MRI represents an effective tool for differentiating MSA from PD.
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등록된 정보가 없습니다.
참고문헌 (7)
참고문헌 신청
Ghaemi M / 2002 / Differentiating multiple system atrophy from Parkinson¡?s disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imaging 73 : 51
Gilman S / 1999 / Consensus statement on the diagnosis of multiple system atrophy 163 : 94 ~ 98
Hughes AJ / jneurolneurosurgpsychiatry1992;55181-184 / Accuracy of clinical diagnosis of idiopathic Parkinson¡?s disease a clinico- pathological study of 100 cases
Schocke MF / 2002 / Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD 58 : 575 ~ 580
Schocke MF / 2004 / Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson¡?s disease 2
Gilman S / 1999 / Consensus statement on the diagnosis of multiple system atrophy 163 : 94 ~ 98
Hughes AJ / jneurolneurosurgpsychiatry1992;55181-184 / Accuracy of clinical diagnosis of idiopathic Parkinson¡?s disease a clinico- pathological study of 100 cases
Schocke MF / 2002 / Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD 58 : 575 ~ 580
Schocke MF / 2004 / Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson¡?s disease 2
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