지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 80 - 82 (3page)
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초록· 키워드
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We report here a patient with major depressive disorder who experienced severe adverse effects after the administration of SSRIs (serotonin selective reuptake inhibitors) without improvement of his depressive symptoms. These adverse effects disappeared and his depressive symptoms improved after discontinuation of the SSRIs and the administration of tianeptine. The patient exhibited a low value for the loudness dependent of auditory evoked potentials (LDAEP) -0.14 at baseline, which means that his central serotonergic neurotransmission was already highly active. We assumed that it was this high serotonergic activity that rendered him unresponsive to SSRIs, and brought on him the adverse effects, and that the tianeptine was effective due to the lack of serotonin reuptake inhibitory action. Thus, we suggest that LDAEP can be used to predict an individual patient’s tolerability and clinical response to SSRIs in major depression.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Gallinat J. / 2000 / The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression / Psychopharmacology (Berl) 148 :
Hegerl U. / 1993 / Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: a new hypothesis / Biol Psychiatry 33 : 173 ~
Hegerl U. / 2001 / Event-related potentials. Do they reflect central serotonergic neurotransmission and do they predict clinical response to serotonin agonists? / J Affect Di
Juckel G. / 2003 / Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity / Schizophr Res 64 : 115 ~
Juckel G. / 2007 / Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked poten
Hegerl U. / 1993 / Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: a new hypothesis / Biol Psychiatry 33 : 173 ~
Hegerl U. / 2001 / Event-related potentials. Do they reflect central serotonergic neurotransmission and do they predict clinical response to serotonin agonists? / J Affect Di
Juckel G. / 2003 / Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity / Schizophr Res 64 : 115 ~
Juckel G. / 2007 / Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked poten
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