지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 73 - 79 (7page)
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초록· 키워드
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Objective With respect to the pharmacotherapy of social anxiety disorder (SAD), it has been suggested that treatment duration is an important factor that can significantly predict responses. The present study aimed to compare the treatment adherence of SAD patients who were taking either SSRIs or reversible inhibitors of MAO-A (moclobemide) by measuring treatment duration and all-cause discontinuation rates of pharmacotherapy in a natural clinical setting.
Methods We retrospectively analysed the data of 172 patients diagnosed with SAD. Depending on their medication, we divided the patients into two groups, SSRI (n=54) or moclobemide (n=118). The expected number of all-cause discontinuation every 2 weeks after starting treatment was calculated by life table survival methods. A multi-variable Cox proportional hazard regression was used to analyze the potential influence of explanatory variables.
Results Treatment duration was significantly longer in the SSRI group [46.41±56.96, median=12.0 (weeks)] than in the moclobemide group [25.53±34.74, median=12.0 (weeks), Z=2.352, p=0.019]. Overall, all-cause discontinuation rates were significantly lower with SSRIs (81%) than moclobemide (96%, χ2=4.532, p=0.033).
Conclusion The SSRI group had a longer treatment duration and lower all-cause discontinuation rate than moclobemide. Further, only the type of medication had a significant effect on all-cause discontinuation rates and therefore, we could predict better treatment adherence with the SSRIs in the treatment of SAD.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ackerman DL. / 1994 / Predictors of treatment response in obsessive-compulsive disorder: multivariate analyses from a multicenter trial of clomipramine / J Clin Psychopharma
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition / American Psychiatric Press
Atmaca M. / 2002 / Efficacy of citalopram and moclobemide in patients with social phobia: some preliminary findings / Hum Psychopharmacol 17 : 401 ~ 405
Blanco C. / 2003 / The evidence-based pharmacological treatment of social anxiety disorder / Int J Neuropsychopharmacol 6 : 427 ~ 442
Bouwer C. / 1998 / Use of the selective serotonin reuptake inhibitor citalopram in the treatment of generalized social phobia / J Affect Disord 49 : 79 ~ 82
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition / American Psychiatric Press
Atmaca M. / 2002 / Efficacy of citalopram and moclobemide in patients with social phobia: some preliminary findings / Hum Psychopharmacol 17 : 401 ~ 405
Blanco C. / 2003 / The evidence-based pharmacological treatment of social anxiety disorder / Int J Neuropsychopharmacol 6 : 427 ~ 442
Bouwer C. / 1998 / Use of the selective serotonin reuptake inhibitor citalopram in the treatment of generalized social phobia / J Affect Disord 49 : 79 ~ 82
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