지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 8 - 16 (9page)
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초록· 키워드
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Consumption of large amounts of alcohol is known to have negative effects, but consumption in smaller amounts may be protective. The effect of alcohol may be greater in the elderly than in younger adults, particularly with regard to cognition. However, the drinking pattern that will provide optimal protection against dementia and cognitive decline in the elderly has not been systematically investigated. The present paper is a critical review of research on the effect of alcohol on cognitive function and dementia in the elderly. Studies published from 1971 to 2011 related to alcohol and cognition in the elderly were reviewed using a PubMed search. Alcohol may have both a neurotoxic and neuroprotective effect. Longitudinal and brain imaging studies in the elderly show that excessive alcohol consumption may increase the risk of cognitive dysfunction and dementia, but low to moderate alcohol intake may protect against cognitive decline and dementia and provide cardiovascular benefits. Evidence suggesting that low to moderate alcohol consumption in the elderly protects against cognitive decline and dementia exists; however, because of varying methodology and a lack of standardized definitions, these findings should be interpreted with caution. It is important to conduct more, well-designed studies to identify the alcohol drinking pattern that will optimally protect the elderly against cognitive decline and dementia.
목차
등록된 정보가 없습니다.
참고문헌 (123)
참고문헌 신청
Robinson JK. / 1992 / MK-801 prevents brain lesions and delayed-nonmatching-to-sample deficits produced by pyrithiamine-induced encephalopathy in rats / Behav Neurosci 106:623~633
Kopelman MD. / 2009 / The Korsakoff syndrome: clinical aspects, psychology and treatment / Alcohol Alcohol 44:148~154
Anttila T. / 2004 / Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study / BMJ 329:539
Mahley RW. / 1999 / Is epsilon4 the ancestral human apoE allele? / Neurobiol Aging 20:429~430
Bleich S. / 2005 / Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS) / Alcohol Clin Exp Res 29:334~336
Kopelman MD. / 2009 / The Korsakoff syndrome: clinical aspects, psychology and treatment / Alcohol Alcohol 44:148~154
Anttila T. / 2004 / Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study / BMJ 329:539
Mahley RW. / 1999 / Is epsilon4 the ancestral human apoE allele? / Neurobiol Aging 20:429~430
Bleich S. / 2005 / Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS) / Alcohol Clin Exp Res 29:334~336
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