지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives The aim of this study is to investigate correlation between the location of white matter hyperintensities (WMH) and neurocognitive dysfunction in non-demented Korean vascular depression patients.
Methods A total of 148 subjects diagnosed with first major depressive episode after the age of 60 were included in this study. Subjects were divided into the vascular depression group (n=83) and the non-vascular depression group (n=65) according to the degree of WMH. The degree and location of WMH on T2-weighted images were measured using the Scheltens scale. In addition, several clinical features, including cognitive functions and depression severities, were evaluated. Correlation analysis was performed for examination of the relationships between the location of WMH and neuropsychological functions.
Results Capsular frontal periventricular hyperintensities showed correlation with poorer performance of the word list memory test, constructional recall test, and trail making test A and B.
Lateral ventricular hyperintensities showed correlation with poorer performance of verbal fluency test, word list recognition test, and trail making test B. Deep WMH, especially parietal and occipital lesions, showed an association with poorer performance on trail making test B. In addition,deep WMH, but not periventricular WMH, showed an association with Hamilton Depression Scale score.
Conclusion Our results suggest that subjects with vascular depression showed significantly poorer performance on neurocognitive tests than those with non-vascular depression. In addition,WMH, depending on their locations, showed different correlations according to details of cognitive dysfunction and severity of depressive symptoms.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Alexopoulos GS / 1997 / ‘Vascular depression’ hypothesis / Arch Gen Psychiatry 54 : 915 ~ 922
Baxter LR Jr / 1989 / Reduction of prefrontal cortex glucose metabolism common to three types of depression / Arch Gen Psychiatry 46 : 243 ~ 250
Butters MA / 2008 / Pathways linking late-life depression to persistent cognitive impairment and dementia / Dialogues Clin Neurosci 10 : 345 ~ 357
Conway CR / 1999 / Geriatric depression: further evidence for the ‘vascular depression’ hypothesis / Current Opinion in Psychiatry 12 : 463 ~ 470
Cook IA / 2004 / Longitudinal progression of subclinical structural brain disease in normal aging / Am J Geriatr Psychiatry 12 : 190 ~ 200
Baxter LR Jr / 1989 / Reduction of prefrontal cortex glucose metabolism common to three types of depression / Arch Gen Psychiatry 46 : 243 ~ 250
Butters MA / 2008 / Pathways linking late-life depression to persistent cognitive impairment and dementia / Dialogues Clin Neurosci 10 : 345 ~ 357
Conway CR / 1999 / Geriatric depression: further evidence for the ‘vascular depression’ hypothesis / Current Opinion in Psychiatry 12 : 463 ~ 470
Cook IA / 2004 / Longitudinal progression of subclinical structural brain disease in normal aging / Am J Geriatr Psychiatry 12 : 190 ~ 200
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