지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 249 - 256 (8page)
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초록· 키워드
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Background and Purpose Involvement of the corpus callosum (CC) is reported to be aconsistent feature of amyotrophic lateral sclerosis (ALS). We examined the CC pathology using diffusion tensor tractography analysis to identify precisely which fiber bundles are involvedin ALS.
Methods Diffusion tensor imaging was performed in 14 sporadic ALS patients and 16 agematched healthy controls. Whole brain tractography was performed using the multiple-regionof interest (ROI) approach, and CC fiber bundles were extracted in two ways based on functional and structural relevance: (i) cortical ROI selection based on Brodmann areas (BAs), and(ii) the sulcal-gyral pattern of cortical gray matter using FreeSurfer software, respectively.
Results The mean fractional anisotropy (FA) values of the CC fibers interconnecting the primary motor (BA4), supplementary motor (BA6), and dorsolateral prefrontal cortex (BA9/46)were significantly lower in ALS patients than in controls, whereas those of the primary sensorycortex (BA1, BA2, BA3), Broca’s area (BA44/45), and the orbitofrontal cortex (BA11/47) didnot differ significantly between the two groups. The FreeSurfer ROI approach revealed a verysimilar pattern of abnormalities. In addition, a significant correlation was found between themean FA value of the CC fibers interconnecting the primary motor area and disease severity, asassessed using the revised Amyotrophic Lateral Sclerosis Functional Rating Scale, and theclinical extent of upper motor neuron signs.
Conclusions Our findings suggest that there is some degree of selectivity or a gradient in theCC pathology in ALS. The CC fibers interconnecting the primary motor and dorsolateral prefrontal cortices may be preferentially involved in ALS.
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참고문헌 (25)
참고문헌 신청
Beaulieu C / 2002 / The basis of anisotropic water diffusion in the nervous system - a technical review / NMR Biomed 15 : 435 ~ 455
Brodmann K / 2006 / Brodmann’s Localisation in the Cerebral Cortex:the Principles of Comparative Localisation in the Cerebral Cortex Based on the Cytoarchitectonics / Springer
Brooks BR / 2000 / El Escorial revisited:revised criteria for the diagnosis of amyotrophic lateral sclerosis / Amyotroph Lateral Scler Other Motor Neuron Disord 1 : 293 ~ 29
Cedarbaum JM / 1999 / The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III) / J Neurol
Ciccarelli O / 2009 / Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics / Hum Brain Mapp 30 : 615 ~ 624
Brodmann K / 2006 / Brodmann’s Localisation in the Cerebral Cortex:the Principles of Comparative Localisation in the Cerebral Cortex Based on the Cytoarchitectonics / Springer
Brooks BR / 2000 / El Escorial revisited:revised criteria for the diagnosis of amyotrophic lateral sclerosis / Amyotroph Lateral Scler Other Motor Neuron Disord 1 : 293 ~ 29
Cedarbaum JM / 1999 / The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III) / J Neurol
Ciccarelli O / 2009 / Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics / Hum Brain Mapp 30 : 615 ~ 624
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