지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 175 - 188 (14page)
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초록· 키워드
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Many recent epidemiological studies have found the prevalence of depression and anxiety to behigher in people with epilepsy (PWE) than in people without epilepsy. Furthermore, people withdepression or anxiety have been more likely to suffer from epilepsy than those without depression or anxiety. Almost one-third of PWE suffer from depression and anxiety, which is similar tothe prevalence of drug-refractory epilepsy. Various brain areas, including the frontal, temporal,and limbic regions, are associated with the biological pathogenesis of depression in PWE. It hasbeen suggested that structural abnormalities, monoamine pathways, cerebral glucose metabolism, the hypothalamic-pituitary-adrenal axis, and interleukin-1b are associated with the pathogenesis of depression in PWE. The amygdala and the hippocampus are important anatomicalstructures related to anxiety, and γ-aminobutyric acid and serotonin are associated with its pathogenesis. Depression and anxiety may lead to suicidal ideation or attempts and feelings of stigmatization. These experiences are also likely to increase the adverse effects associated with antiepileptic drugs and have been related to poor responses to pharmacological and surgical treatments.
Ultimately, the quality of life is likely to be worse in PWE with depression and anxiety than inPWE without these disorders, which makes the early detection and appropriate management ofdepression and anxiety in PWE indispensable. Simple screening instruments may be helpful forin this regard, particularly in busy epilepsy clinics. Although both medical and psychobehavioraltherapies may ameliorate these conditions, randomized controlled trials are needed to confirmthat.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Cleary RA / 2012 / Predictors of psychiatric and seizure outcome following temporal lobe epilepsy surgery / Epilepsia 53 : 1705 ~ 1712
Edeh J / 1987 / Relationship between interictal psychopathology and the type of epilepsy. Results of a survey in general practice / Br J Psychiatry 151 : 95 ~ 101
Ettinger A / 2004 / Depression and comorbidity in community-based patients with epilepsy or asthma / Neurology 63 : 1008 ~ 1014
Gaitatzis A / 2004 / The epidemiology of the comorbidity of epilepsy in the general population / Epilepsia 45 : 1613 ~ 1622
Gaitatzis A / 2004 / The psychiatric comorbidity of epilepsy / Acta Neurol Scand 110 : 207 ~ 220
Edeh J / 1987 / Relationship between interictal psychopathology and the type of epilepsy. Results of a survey in general practice / Br J Psychiatry 151 : 95 ~ 101
Ettinger A / 2004 / Depression and comorbidity in community-based patients with epilepsy or asthma / Neurology 63 : 1008 ~ 1014
Gaitatzis A / 2004 / The epidemiology of the comorbidity of epilepsy in the general population / Epilepsia 45 : 1613 ~ 1622
Gaitatzis A / 2004 / The psychiatric comorbidity of epilepsy / Acta Neurol Scand 110 : 207 ~ 220
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