지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 301 - 304 (4page)
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초록· 키워드
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Background and Purpose Migraine patients are particularly prone to the complication of medication-overuse headache (MOH). Although it has been shown that A allele carriers for the tumor necrosis factor (TNF)-β gene G252A polymorphism are at high risk of the development of migraine without aura, the relationship between the TNF-β gene G252A polymorphism and MOH is unknown. We investigated whether the TNF-β gene G252A polymorphism is involved in the aggravation of migraine by overuse of medications.
Methods Forty-seven migraine patients (6 males and 41 females; age 36.4±10.3 years, mean±SD) and 22 MOH patients (1 male and 21 females; age 39.6±9.9 years) who had migraine were included in this study. The genotype for the TNF-β gene G252A polymorphism was determined by polymerase-chain-reaction restriction-fragment-length polymorphism analysis.
Results The distribution of TNF-β gene G252A genotype frequency differed significantly between migraine and MOH patients (p=0.013). The G/G genotype was carried by 23% of the migraine patients but it was absent in MOH patients.
Conclusions G/G genotype carriers appear to be less susceptible to the aggravation of migraine by overuse of medications. The G252A TNF-β gene polymorphism may be one of the factors contributing to the complications of MOH in patients with migraine.
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참고문헌 (17)
참고문헌 신청
Abraham LJ / 1993 / Polymorphic MHC ancestral haplotypes affect the activity of tumour necrosis factor-alpha / Clin Exp Immunol 92 : 14 ~ 18
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. 4th ed / American Psychiatric Association
Asuni C / 2009 / Migraine and tumour necrosis factor gene polymorphism. An association study in a Sardinian sample / J Neurol 256 : 194 ~ 197
Bahra A / 2003 / Does chronic daily headache arise de novo in association with regular use of analgesics? / Headache 43 : 179 ~ 190
Grimble RF / 2002 / The ability of fish oil to suppress tumor necrosis factor α production by peripheral blood mononuclear cells in healthy men is associated with polymorph
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. 4th ed / American Psychiatric Association
Asuni C / 2009 / Migraine and tumour necrosis factor gene polymorphism. An association study in a Sardinian sample / J Neurol 256 : 194 ~ 197
Bahra A / 2003 / Does chronic daily headache arise de novo in association with regular use of analgesics? / Headache 43 : 179 ~ 190
Grimble RF / 2002 / The ability of fish oil to suppress tumor necrosis factor α production by peripheral blood mononuclear cells in healthy men is associated with polymorph
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