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Background and PurposezzEvaluating respiratory function is important in neuromuscular diseases. Tis study explored the reference ranges of the maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and snif nasal inspiratory pressure (SNIP) in healthy adults, and applied them to amyotrophic lateral sclerosis (ALS) patients. MethodszzMIP, MEP, and SNIP were measured in 67 healthy volunteers aged from 21 to 82 years. Reference ranges were evaluated by multivariate regression analysis using the generalized additive modeling of location, scale, and shape method. Tirty-six ALS patients were reviewed retrospectively, and abnormal values of MIP, MEP, and SNIP were determined according to the reference ranges. ResultszzMIP, MEP, and SNIP were abnormal in 57.1%, 51.4%, and 25.7% of the ALS patients, respectively. MIP and SNIP were signifcantly correlated with the degree of restrictive pattern and respiratory symptoms. Te ALS Functional Rating Scale-Revised score was correlated with SNIP. ConclusionszzTis study has provided the reference range of respiratory muscle strength in healthy adults. Tis range is suitable for evaluating respiratory function in ALS patients.

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