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학술저널
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대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제9권 제4호
발행연도
2013.1
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223 - 230 (8page)

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Background and Purpose Atherothrombotic cerebral infarction [atherothrombotic stroke (ATS)] shares common risk factors and pathophysiological mechanisms with coronary artery disease (CAD), and both diseases appear to have common susceptibility loci. The muscle RAS oncogene homolog gene (MRAS) has been identified as a susceptibility locus for CAD and is implicated in atherosclerosis. The aim of this study was to elucidate whether the single-nucleotide polymorphisms (SNPs) and haplotypes of MRAS are associated with increased risk of ATS in a population of Han Chinese. Methods A case-controlled association study was conducted in which only patients with ATS (identified as a major subtype in the Korean modification of the Trial of Org 10172 in Acute Stroke Treatment classification) were enrolled. Subgroup analyses were carried out to determine whether the effect of the MRAS polymorphism was specific to age and gender among the subjects. Results In total, 194 ATS and 186 control subjects were included in the present study. Two tagging SNPs were identified in MRAS (rs40593 and rs3755751). A multivariate regression analysis revealed a positive association between rs40593 and ATS under dominant and additive models after adjustment for covariates. Subgroup analyses revealed that there were no gender differences with respect to allele or genotype frequencies between the groups. The AG genotype for rs40593(p=0.028), the CT genotype for rs3755751 (p=0.036), and G-allele carriers (AG plus GG) for rs40593 (p=0.015) exhibited a significant protective effect among those aged ≥45 years. For the haplotype analysis, ATS subjects aged ≥45 years had a higher frequency of the ACAC haplotype (76.0%) than the controls (68.1%; p<0.05); that haplotype was associated with an increased risk of ATS. Conclusions The obtained data suggest a positive association between MRAS and ATS among the Han Chinese. Further studies should be performed with larger sample and among different ethnic populations, and gene-gene or gene-environment interactions should be considered.
#ischemic stroke #atherothrombotic stroke #single-nucleotide polymorphism #haplotype #genetic variation.

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참고문헌 (23)

참고문헌 신청
Adams RJ / 2003 / Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke google schola Alberti KG / 1998 / Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: google schola Anderson CD / 2010 / Chromosome 9p21 in ischemic stroke: population structure and metaanalysis / Stroke 41 : 1123 ~ 1131 google schola Asplund K / 1988 / Diagnostic criteria and quality control of the registration of stroke events in the MONICA project / Acta medica Scandinavica Supplementum 728 : 26 ~ 39 google schola Bevan S / 2008 / Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls / Stroke 39 : 1966 ~ 1971 google schola

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