지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 210 - 214 (5page)
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초록· 키워드
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Background and Purpose Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited microangiopathy caused by mutations in the Notch3 gene. Although previous studies have shown an association between lacunar infarction and cognitive impairment, the relationship between MRI parameters and cognition remains unclear. In this study we investigated the influence of MRI parameters on cognitive impairment in CADASIL.
Methods We applied a prospective protocol to 40 patients. MRI analysis included the normalized volume of white-matter hyperintensities (nWMHs), number of lacunes, and number of cerebral microbleeds. Cognition was assessed with the aid of psychometric tests [Mini-Mental State Examination (MMSE), Alzheimer’s Disease Assessment Scale-cognition (ADAS-cog), Trail-Making Test, and Stroop interference (Stroop IF)].
Results A multivariate regression analysis revealed that the total number of lacunes influenced the performance in the MMSE, ADAS-cog, and Stroop IF, while nWMHs had a strong univariate association with ADAS-cog and Stroop IF scores. However, this association disappeared in the multivariate analysis.
Conclusions These findings demonstrate that the number of lacunes is the main predictive factor of cognitive impairment in CADASIL.
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참고문헌 (22)
참고문헌 신청
Benisty S / 2008 / Diagnostic criteria of vascular dementia in CADASIL / Stroke 39 : 838 ~ 844
Bokura H / 1998 / Distinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: a magnetic resonance imaging and pathological study / J Neurol 245 : 116 ~ 122
Chabriat H / 1995 / Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy / Lancet 3
Golden C / 2002 / Stroop Color and Word Test / Stoelting
Joutel A / 1996 / Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia / Nature 383 : 707 ~ 710
Bokura H / 1998 / Distinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: a magnetic resonance imaging and pathological study / J Neurol 245 : 116 ~ 122
Chabriat H / 1995 / Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy / Lancet 3
Golden C / 2002 / Stroop Color and Word Test / Stoelting
Joutel A / 1996 / Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia / Nature 383 : 707 ~ 710
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